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[SA_scat] PhD Studentship in CONFORMATION AND INTERACTIONS OFCONTROLLED RELEASE POLYMERS IN SOLUTION AND BARRIER FILMS

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  • Subject: [SA_scat] PhD Studentship in CONFORMATION AND INTERACTIONS OFCONTROLLED RELEASE POLYMERS IN SOLUTION AND BARRIER FILMS
  • From: <stephen.king@stfc.ac.uk>
  • Date: Wed, 27 Feb 2013 15:50:23 +0000
  • Accept-Language: en-GB, en-US
PhD Studentship, 3 years



CONFORMATION AND INTERACTIONS OF CONTROLLED RELEASE POLYMERS IN SOLUTION AND BARRIER FILMS



Project Description:

Multi-particulates are solid oral dosage forms consisting of a multiplicity of small discrete units (pellets) that are typically encapsulated to give the final product with desired dose. Pellets can be tailored for pulsatile, controlled, delayed and targeted drug release depending upon the polymer(s) employed during manufacture. An intimate understanding of the properties of the controlled release (CR) film formation is critical to ensure consistent performance (e.g. drug release & stability) of the product as the project progresses from pilot scale through to successful product launch.



A modified release film coat contains three main components: film former, permeability enhancer and plasticizer. The most common film former is ethylcellulose (EC). Various permeability enhancers have been used, of which hydroxypropyl methylcellulose (HPMC) is the most common. Differences in film preparation, such as the solvent system used, impact on the level of dispersion of the two components, the resultant film properties and hence properties such as drug release rate, mechanical integrity etc. Therefore, understanding the relative strengths of the polymer-polymer, polymer-solvent and polymer-drug interaction in these complex blends is critical. This project will quantify these interactions using spectroscopic methods such as NMR & neutron scattering (SANS).


You will be joining a dynamic group that has wide-ranging interests spanning drug delivery to motor engine products. The group uses a range of powerful experimental methodology to characterise these systems, in particular small-angle neutron scattering (ISIS, Oxfordshire, UK & ILL, Grenoble, France) and NMR, as well as more routine techniques such as rheology, surface tension etc.

Closing date for applications:
12.00 UTC on Friday 8 March 2013


Making an application:

An application form is available at: http://www2.gre.ac.uk/research/study/apply/application_process
This should be completed and returned by e-mail to postgraduateresearch@gre.ac.uk<mailto:postgraduateresearch@gre.ac.uk>
Any attachments should be in Word or PDF format.

For further information:
Professor Peter Griffiths
University of Greenwich

p.griffiths@gre.ac.uk<mailto:p.griffiths@gre.ac.uk>



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