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[SA_Scat] =?windows-1252?q?Postdoctoral_Position_=96_Synchrotron_?==?windows-1252?q?scattering_and_analysis?=

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  • Subject: [SA_Scat] =?windows-1252?q?Postdoctoral_Position_=96_Synchrotron_?==?windows-1252?q?scattering_and_analysis?=
  • From: <stephen.king@stfc.ac.uk>
  • Date: Thu, 21 Jan 2016 21:24:11 +0000
  • Accept-Language: en-GB, en-US
Postdoctoral Position – Synchrotron scattering and analysis
Monash University, Parkville Campus, Melbourne, Australia7th Jan 2016
The group is interested in structured materials for drug delivery applications, and conducts material science (materials design and characterization), in vitro evaluation (drug loading and release, cell interactions) and in vivo evaluation (bioavailability, disease models). We currently have four postdocs and ten PhD students in the group as well as two technicians. The group (see nonlamellar.com) is led by Professor Ben Boyd and is part of the Drug Delivery, Disposition and Dynamics theme of Monash Institute of Pharmaceutical Sciences.
The project is funded through the Australian Research Council for three years, and will involve the investigation of colloidal structures formed during digestion of milk and their link to compositional changes and nutritional outcomes. We have recently discovered the formation of complex geometric self-assembly structures during the digestion of cow and human milk using real-time synchrotron SAXS here in Melbourne at the Australian Synchrotron, to obtain high resolution kinetic data and to try to study these systems in situ during the digestion process. The structures that form depend very much on the lipid composition in the milk and the sensitivity of changes in composition (lipids, salt, sugar, protein) are not well understood. These issues are believed to be important in the delivery of poorly soluble nutrients and lipids themselves from the gut, and hence are an important aspect of understanding human nutrition. The structures are dynamic and often complex mixtures of micelles, liposomes, emulsion droplets and ordered particles such as cubic phase particles and hexagonal phase particles, so the major challenge will be to try to deconvolute some of these systems and obtain structural data on the multiple populations.
The right person will have extensive experience with using scattering modelling approaches and common software. This must be demonstrated, and could be SANS/NR but preferably SAXS. Preferably they will have synchrotron experience as although a PhD student will take most of the hands on experimental burden, the postdoc will definitely help with planning, contributing ideas to improve experimental configuration and take part in experiments, often overnight. Some aligned expertise would be valuable, such as cryoTEM or other imaging techniques. Experience in lipid analytical techniques such as LC-MS or GC-MS would be an advantage. The postdoc would have around 20% of time to pursue their own interests in this area as well as contribute to other projects in the group as appropriate.
The starting salary will be commensurate with experience and in line with Monash University salary rates which can be accessed via monash.edu. Some relocation assistance may also be available. The position is available as soon as the right candidate is found.
If interested in this position, please contact ben.boyd@monash.edu or see nonlamellar.com for more details

Professor Ben J. Boyd
Drug Delivery, Disposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University (Parkville Campus)381 Royal Parade, ParkvilleVictoria 3052, Australia
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