Event Name

Solution scattering from biological macromolecules. EMBO Practical Course

Start Date 27th Oct 2014
End Date 3rd Nov 2014

About the practical course

The EMBO Practical Course is aimed at young scientists working in the field of structural biology including: biochemists, biophysicists, and those specializing in macromolecular crystallography (MX), electron microscopy (EM), NMR or bioinformatics. Small angle scattering (SAS) of X-rays and neutrons (SAXS/SANS) experiences a renaissance in structural biology allowing one to study native particles and complexes and to monitor structural changes in response to variations in external conditions (temperature, pH, salinity, ligands).

Novel data analysis methods and a broader accessibility to high brilliance instruments on large scale facilities significantly enhanced resolution and reliability of structural models provided by SAS. Emerging automation of the experiment, data processing and interpretation made solution SAS a streamline tool for large scale structural studies in molecular biology. The method provides low resolution macromolecular shapes ab initio and is readily combined with other structural, biochemical and computational techniques in hybrid approaches. The extremely broad range of molecular sizes accessible by SAS, from kDa to GDa, allows one to monitor the interactions in hierarchical systems at different levels of structural organization. The participants are encouraged to bring their own samples for biophysical characterization (e.g. using light scattering, size exclusion chromatography and thermoflour experiments). They may also bring the SAXS or SANS data collected on other facilities to be analysed during the Course.

Location Hamburg
Contact Margret Fischer
URL http://events.embo.org/14-sas/index.html

Category Training courses
Topics Biological macromolecules | Neutron scattering | Small-angle scattering