Event Name

Fundamentals of Modern Methods of Biocrystallography - BioCrys 2010

Start Date 9th Oct 2010
End Date 16th Oct 2010
The fifth BioCrys course will be focused on Macromolecular Crystallography, by developing the fundamental concepts of Crystallography and illustrate these by tutorial and practical sessions.

This is particularly important due to the rapid development of the field and also due to the fact that many young researchers do not receive a formal education in Crystallography. Additionally, with the introduction of high-throughput methods, the need to understand and grasp the theory behind modern methods will certainly be critical to overcome the difficult problems that will arise and will not be solved by the automated procedures.

Topics of the course will run from fundamentals such as symmetry, point groups and crystal systems, basic diffraction physics, reciprocal space and the Ewalds sphere, radiation damage, data processing, symmetry in the diffraction pattern, structure factors, Patterson function to modern methodologies including molecular replacement, SAD, MAD, MIR and maximum likelihood phasing, direct methods, density modification, refinement, model building, twinning and structure validation.

The course will be organized with lectures in the mornings and interactive practicals and tutorials in the afternoons. Evening lectures on current topics will be presented by the invited speakers. Participants will be limited to 36, aimed primarly at people at the beginning of their crystallographic research activity as PhD students or others. Selected applicants are invited to present a poster during the course.
Location Oeiras
URL http://biocrys2010.itqb.unl.pt/

Category IUCr sponsored meetings | Schools | Training courses
Topics Biological macromolecules