IUCr journals

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1

Acta Cryst. (2005). F61, 14–16 [doi:10.1107/S1744309104030659]

[M. loti NAT 1] Secondary structure representation of M. loti NAT1 (mauve) superimposed with other published NAT structures.
Arylamine N-acetyltransferases (NATs), first identified through their ability to inactivate the anti-tubercular therapy isoniazid, have now been observed in a broad range of prokaryotic and eukaryotic species. This article presents the 1.8 Å structure of NAT1 from Mesorhizobium loti, a nitrogen-fi xing bacterium that lives in symbiosis with leguminous plants. Despite low sequence identity, the NAT1 structure is remarkably well conserved with that of other NATs. This structure adds to the growing number of published NAT structures and will complement current work at identifying bacterial NAT antagonists.

S. Holton, J. Dairou, J. Sandy, F. Rodrigues-Lima, J.-M. Dupret, M. Noble and E. Sim