IUCr journals

Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

Acta Cryst. (2006). F62, 180–185 [doi:10.1107/S1744309106005847]

[P. falciparum]This structure establishes a mapping of sequence family PF05907 onto a novel fold containing 15 β-strands in 4 sheets.
The structure of P. falciparum MAL13P1.257 is the first structure determined for a member of Pfam sequence family PF05907. The biological function of these proteins is unknown. The structure is almost entirely β-sheet and represents a new protein fold. There are two regions of high sequence conservation with other family members. One forms a hydrophobic core; the second contains both core and surface residues. Curiously, several distinctive sequence motifs that are highly conserved across other family members are not present in the P. falciparum protein.

M. A. Holmes, F. S. Buckner, W. C. Van Voorhis, C. Mehlin, E. Boni, T. N. Earnest, G. DeTitta, J. Luft, A. Lauricella, L. Anderson, O. Kalyuzhniy, F. Zucker, L. W. Schoenfeld, W. G. J. Hol and E. A. Merrit