IUCr journals

Conformational change of the AcrR regulator reveals a possible mechanism of induction

Acta Cryst. (2008). F64, 584–588 (doi.org/10.1107/S1744309108016035)

[E. coli AcrR] Structural comparison of the P31 and P2221 structures of AcrR.
Escherichia coli AcrR represses transcription of acrAB and is induced by many structurally unrelated cytotoxic compounds. The crystal structure of this regulator in space group P2221 has been reported previously, revealing a dimeric two-domain molecule with an entirely helical architecture similar to members of the TetR family of transcriptional regulators. Here, a crystal structure of this regulator in space group P31 is presented. A comparison of the two AcrR structures reveals possible mechanisms of ligand binding and AcrR regulation.

R. Gu, M. Li, C.-C. Su, F. Long, M.D. Routh, F. Yang, G. McDermott and E.W. Yu