On the cover
The full range of crystallographic research to be presented at the XVIII Congress of the International Union in Glasgow, August 4-13, 1999, is reflected in these illustrations (composite by Patricia Coley). Clockwise beginning at upper left: (1) Ribbon drawing of FepA, an active transporter of ferric enterobactin in the outer membrane of E. coli. S.K. Buchanan et al. (1999) Nature Structural Biology 6:56. Courtesy of Hans Deisenhofer. (2) Neutron quasi-Laue diffraction pattern from tetragonal hen egg-white lysozyme revealed 960 hydrogen atoms and 251 water molecules. N. Niimura et al., Nature Structural Biology, Vol.4, No. 11, 1997, pp 909-914. Courtesy of N. Niimura. (3) Anisotropic Displacement Parameters (ADP) of anthraquinone between 160 and 300K (Brock and Fu, Acta Cryst. B54 (1998) 308) shows butterfly-type motion of the molecule (S.C. Capelli, PhD thesis, U. of Bern, Switzerland, 1999). Picture by J. Hauser. Courtesy of H.-B Bürgi. (4) A 24-nucleotide RNA enzyme, Leadzyme, complexed with Sr(H2O)3(II) at 1.8 Å resolution reveals how small ribozymes recruit metals to activate specific 2'-hydroxyl groups for nucleophilic attack leading to phosphodiester scission. The substrate has a purple electron density surface and yellow nucleotide bonds. The ribozyme, a yellow electron density surface and pink nucleotide bonds. Courtesy of David McKay. (5) The hydrate of 18-crown-6/methylammonium fluoride, a channel structure in which water molecules form a 'double helix' along the crystallographic z axis. Courtesy of Janusz Lipkowski. (6) A model of a surfactant templated silicate structure at the air water interface of a cetyl trimethyl ammonium solution being studied by X-ray and neutron reflectivity. Courtesy of John White. (7) A very-large-pore high-silica zeolite UTD-1 bis(pentamethylcyclopentadienyl)cobalt(III) complex solved ab initio from powder diffraction data collected on a textured sample. Courtesy of Lynne B. McCusker. (8) The end of the myosin power stroke from crystal structure analysis of actin and myosin and electron microscopy of the actin-myosin complex. Courtesy of Ken Holmes.
Editorial and production
William L. Duax Editor
N.M. Allinson, H. Berman, P. Bourne, I.D. Brown, E. Dodson, V. Evsyunin, R.B. Ferguson, G. Gilliland, A. Hamilton, J. Hauser, A. Hunter, A. Kashaev, W. Melik-Adamyam, A. Mishnev, R. Nelmes, G. Newton, J. Parise, V. Pattabhi, D. Poleti, J. Pons, A. Revenko, and T. Safonova.