Miscellany

Spo0F proof?

Tired of the reliable but presumed static data on macromolecules provided by X-ray analysis? Biochemists are using NMR dynamics studies to probe relationships between molecule movement and function. Feher and Cavanagh [Nature, 400, 289-293 (1999)] detect amino acid residues moving on a microsecond to millisecond timescale in a protein involved in a phospho-relay signal transduction pathway in Bacillus subtilis. The moving residues correspond to amino acids previously identified as important in mediating interaction with three signaling partners. Is there a hidden significance to the fact that the acronym for the protein under study is known as Spo0F?