STRUCTURE OF THREE BIOACTIVE FURANIC BIDERIVATIVES. Julio Duque Rodríguez^*, Ramón Pomés Hernández, National Center for Scientific Research. P.O.Box 6990. Havana. Cuba, Hector Novoa de Armas, Center of Pharmaceutical Chemistry. P.O.Box 16042, Havana, Cuba, Raúl Alfredo Toscano, Institute of Chemistry, UNAM. 04510, México, D.F.

1-Furfuryl-(6-Amino-3-Cyano-4-Methyithio)-5NFurfurylamidePridin-2-One. H₂O,C₂₀H₂₀O₄N₄S.H₂O, Mr= 252.3, Triclinic, P-1, a= 7.406(2), b= 11.473(2), c= 12.543(4) Å, [[alpha]]= 81.76(3), [[beta]]= 79.62(3), [[gamma]]= 71.20(3)o,V= 7996.1(5) ų, Z=2, Dx= 1.37 mg/m^-3, u= 1.70 mm^-1, R=0.06; N-Bencyl-(2-Cyano-3-(2' Furyl)-Acrylamide), C₁₅H₁₂N₂O₂, Mr= 252.3, Triclinic, P-1, a= 9.805(2), b= 27.542(3), c= 5.010(4) Å, [[alpha]]= 95.64(2), [[beta]]= 104.83(2), [[gamma]]= 88.52(2)[[exclamdown]], V= 1301.5(2) ų, Z=4, Dx= 1.29 mg/m^-3 , u= 0.67 mm^-1, R= 0.074 and Furfuryl-[2-Cyano-3-Furfuryliden]-Acrylamide, C₁₃H₁₀N₂O₃, Mr= 242.23, Triclinic, P-1, a= 5.311(1), b= 9.495(1), c= 11.442(2) Å, [[alpha]]= 94.13(2), [[beta]]= 93.79(2), [[gamma]]= 93.60(2)o, V= 572.9(3) ų, Z= 2, Dx= 1.39 mg/m^-3, u= 0.10 mm^-1, R= 0.041. Have been investigated by single crystal and obtained by synthetic procedures or as constituents of naturally occurring molecules, have been studied and used as drugs showing antimicrobiotic hypotensive and antitumor activity (Bartroli, Lami, Quincoses & Peseke, 1984). The chemical and biological characteristics of these substances can be directry related to the conformation of their molecules and the presents sustituents. The structures were solved used SHELXTL-Plus (Direct Methods) and refinement by full-matrix least-squares.

Bartroli, R., Lami, L., Quincoses, J. & Peseke, K. Cuban Patent. No 21789, Havana, Cuba, 1984