POLYMORPHISM OF THE GOSSYPOL INCLUSION COMPLEXES. B.T.Ibragimov, Z.G.Tiljakov, S.A.Talipov, K.M.Beketov. Institute of Bioorganic Chemistry, H.Abdullaev str., 83, Tashkent,700143, Uzbekistan e-mail:root@ibc.tashkent.su

The inclusion compound formation by gossypol, biologically active substance of cotton, was studied at different thermodynamic conditions. Most of investigated guests form with gossypol more than one inclusion compound. Very often occurred polymorphism of the gossypol host-guest formation with the same guest is dimorphism and thrimorphism. Several examples of such polymorphism will be given. In the case of dichlormethane host-guest complexes of gossypol at different temperatures has been investigated for the same pressure and concentration. Gossypol forms 3 different clathrates within temperature interval 22-36 C. Single crystals of these three modifications (phases) were obtained. The structure of alpha-phase was earlier determined and gamma-phase is isostructural to the inclusioncomplexes of gossypol with benzene. The structure of a beta-phase have been solved now and will be discussed. At ambient conditions gossypol formsunstable tubulates of a alpha-phase; high temperature gamma-phase is stable cage typeclathrate and host-guest complex of a betta-phase is a clathrate of intermediate tubulato-cryptate type.