E0892

CRYSTAL GROWTH AND X-RAY STRUCTURE DETERMINATION OF A SERIES OF BIOLOGICALLY INTERESTING COMPOUNDS. Janet M. Moloney, J. A. K. Howard, R. Cochlin, W. J. Feast. Chemistry Department, University of Durham, South Road, Durham, DH1 3LE, UK.

Crystallogenesis has assumed increasing importance over the past decade. This is chiefly because many large molecules can be obtained as highly pure single crystals for diffraction studies¹. Therefore, the weak intermolecular interactions which govern solid-state structure can be characterised accurately.

The crystallization of peptides and organic molecules is challenging due to the high percentage of lattice solvent, weak intermolecular interactions, pH dependency and and limited solubility in aqueous systems in many cases. The synthetic methodology and background theory of crystal growth will be discussed fully.

The crystal structures of three related branched cyclopentadienyl compounds, determined from low temperature (150K) on a Siemens SMART diffractometer with area detector will be provided. The similarities of these compounds will be compared and details of solid-state packing will be provided.

References:

1. Crystallization of Nucleic Acids and Proteins; A Practical Approach.

Ducruix, A.; Giegé, R.