X-RAY INVESTIGATION OF FUNGICID ACTIVITY OF OXIRANCONTAINING TRIAZOLILALKANES. St. Malinovskii, M. Krimer. Institute of Chemistry Moldavian Acad. Sci. 277028 Kishinev.

Some of cycloalcanoles in the 1-(lH-1,2,4-triazol-1-ilmethil) row display high biological activity. We have elaborated the stereospecific method of I and II oxiranes obtaining. (Selectivity of I formation is 100% and II - 96.5%). We have also elaborated some more diastereomeric oxirans III displaying fungycid activity.

The dependence of activity on conformation distinctions molecules was determined by X-ray method. Different positions of oxirane fragments concerning C-C bond, different stabilization of the triazol cycle and different sistems of H-bonds is the main cause diverse biology activity.