FREE RADICAL CATION TETRACUPRO SALTS OF ANTI-HISTAMINES. Masood Parvez and Aaliya P. Sabir, Department of Chemistry,University of Calgary, Calgary, Alberta, Canada T2N 1N4

The free radical cations of a number of anti-histamines effective on H₁- receptor sites, e.g., clemizole (1), chlorpyramine (2) and triprolidine (3) have been synthesized and the crystal structures of the dications of these drugs in association with CuCl₄^2- determined by the single crystal XRD method.

Crystal data:

(1) C₁₉H₂₁N₃^.CuCl₄, M_r = 496.75, triclinic, P 1, a= 9.595(5), b=

14.008(4), c= 9.413(5) Å, [[alpha]]= 93.53(3), ,[[beta]]= 117.14(4), [[gamma]] =

85.03(3)deg., V= 1121.3(10) ų, Z= 2, D_c = 1.47 Mg m^-3,

[[lambda]](Mo K[[alpha]]) = 0.71069 Å, u= 1.459 mm^-1, R = 0.039, wR = 0.036

for 2388 observed data with I > 3[[sigma]](I).

(2) C₁₆H₂₂ClN₃^.CuCl₄, M_r= 497.18, monoclinic, P21/a, a = 14.355(2),,

b= 7.836(2), c= 20.353(2) Å, [[beta]]= 106.74(1)deg., V = 2192.3(6) ų, Z=

4,D_c= 1.51 Mgm^-3,[[lambda]] (MoK[[alpha]])=0.71069Å, u= 1.610mm^-l, R=

0.036, wR =0.035 for 1212 observed data with I > 3[[sigma]](I).

(3) C₁₉H₂₄N₂^.CuCl₄, M_r = 485.77, monoclinic, P21/n, a= 10.100(2),

b= 11.777(3), c= 18.291(2) Å, [[beta]]= 94.32(1)deg., V= 2169.6(7) ų, Z=

4,D_c= 1.49Mgm_-3, [[lambda]] (MoK[[alpha]])=0.71069Å, u= 1.512mm^-1, R=

0.092, wR= 0.086 for 1176 observed data with I > 3[[sigma]](I).