ABILITY OF SOME SPECIFIC NATURAL STRUCTURES TO INTERACT CONCURENTLY CONTRARY TO DIOXIN. ESR STUDY. Pham The Vung, Nguyen Van Tri, Dinh Pham Thai, Hanoi University of Technology, Ha Van Mao, Dinh Ngoc Lam, Cancer Research Center, Hanoi, Vietnam

On the basis of the ESR experimental results, some new active natural complexes (symbolized XD*) present in special vegetable produces have been revealed. The nucleus structure of these complexes can show an electron Spin combination almost similar to the one of Dioxin (2,3,7,8- TCDD). However, it is especially remarkable that the Spin combination of XD* occupies a quintuplet ground state (S = 4/2) with a deeply negative exchange energy (J < 0). This behaviour opposes entirely to the one of Dioxin possessing a combination of four [[pi]] electron Spins with a singlet ground state (S=0) and a positive exchange energy (J > 0). Special binding complexes of Dioxin to XD* structures have been also observed with a negative exchange energy (J < 0). These [XD*- Dioxin] complexes appear with a very high probability, about 10⁵ times of the one of the [Hemoglobin - Dioxin] complex in human blood and of the [Mn- Porphyrinoprotein - Dioxin] complex in human liver. The properties of these interaction complexes corresponding with the results achieved in some respective experimental clinical studies over a long period of time suggest that the specific natural XD* structures are able to conquer and arrest potently Dioxin molecules, i.e. to interact concurently contrary to the toxicity of Dioxin, namely to its carcinogenous activity. This activity depends on many factors such as the concentration and the lifetime of the XD* state, the kinetic conditions of the surrounding and the interaction.

This research was supported by the National Basis Research, Program in Natural Sciences and from the 10-80 National Committee.