Hands-On Workshop on Cryo-EM based Atomic Modeling

The tutorials will cover practical methods for cryo-EM guided modeling implemented in DireX, NAMD and VMD, and Rosetta, in the form of hands-on tutorials and case studies. In addition, the lectures and hands-on tutorials will introduce the participants to relevant physical concepts, mathematical algorithms, and computational methods, including molecular dynamics simulation, de novo structure determination based on cryo-EM maps, deformable elastic networks, stereochemical validation of proteins and nucleic acids, cross-validation, and quality checks of fitted structures.

Tutors:

MDFF
Klaus Schulten, Ryan McGreevy, Abhishek Singharoy (UIUC)

Rosetta
Frank DiMaio (U Washington)

DireX
Gunnar Schroeder (Forschungszentrum Juelich)

Additional speakers:
Holger Stark (MPI Biophysical Chemistry, Goettingen)
Stefan Raunser (MPI Molecular Physiology, Dortmund)
Friedrich Foerster (MPI Biochemistry, Munich)