CSHL X-ray Methods in Structural Biology Course

This immersive course is an outstanding place to learn both the theoretical and practical aspects of Macromolecular Crystallography because of the extensive lectures from world-renowned teachers, which are combined with hands-on experiments. This 2019 course will be lead by Jim Pflugrath (Rigaku, ret.), Tassos Perrakis (NKI), Paul Adams (LBL), Janet Newman (CSIRO) and an All-Star cast of lecturers. Attendees can expect to participate in a course that is unparalleled in the world, with experts each devoting several days to teaching the fundamentals, theory and practical considerations of crystallographic structure solution.

Topics to be covered include:

• Basic diffraction theory
• Crystallization (proteins, nucleic acids, complexes and membrane proteins)
• Synchrotron X-ray sources and optics
• Data collection and processing
• Structure solution by experimental phasing methods (SAD, MAD, MIR, and others) and molecular replacement
• Electron density maps improvement
• Model building and refinement
• Structure validation
• Coordinate deposition
• Structure presentation

The course is limited to 16 participants due to the very hands-on nature of the experiments and the intimate seminar room and laboratory settings. Please check the above web link for more details. In particular, please note the information about fellowships, scholarships, and stipends that are available. It is often possible for applicants to receive some level of support to help offset the course fee.

This course is supported with funds provided by the National Institute of General Medical Sciences for which we are extremely grateful. Also there are stipends available from the Leona M. and Harry B. Helmsley Charitable Trust and the Howard Hughes Medical Institute to help offset the cost of tuition.Â