Frontiers of Structural Biology in Complex Environments, a symposium at the ACS National Meeting

Decades of careful experimentation and analysis by biophysical chemists
have formed a foundation for contemporary scientists to understand the
structure and function of proteins in the incredibly complex environments
of living organisms. Recent advances in experimental and computational
approaches have made it possible to describe and predict the structure,
dynamics, and interactions of biomolecular assemblies in complex
environments in vitro, in situ, in cells, and in the extracellular
environment. Despite these exciting advances, many challenges remain in
integrating techniques and approaches that span multiple time and length
scales, and in understanding how atomic level changes drive functional
biological outputs in the cellular environment. The symposium will bring
together experimentalists and theorists who apply cutting-edge methods to
determine the structure of biomolecules at or near atomic level precision
in such environments. Speakers will discuss recent progress in the field
and future challenges in the areas (1) atomic resolution studies of large
complexes, (2) biomolecular condensation, (3) in situ studies in cell and
cell-like environments, (4) in vitro cellular environments, and (5)
biophysical experiments in multi-cellular environments.
 
The abstract deadline is October 17, 2022