We bring together experts at the intersection of microscopy and mass spec, topics include soft landing, holography, cryoEM, AFM, native MS, top-down proteomics and various single molecule imaging and mass spectrometry techniques to characterize (biological) macromolecules.

The TR+ workshop will provide exciting insight into the broad range of synchrotron-based techniques available at MAX IV to investigate dynamics on a variety of length scales and timescales in biomolecules using X-ray spectroscopy, scattering, serial crystallography, and combined methods.

This workshop will focus on the practical considerations in performing time-resolved synchrotron studies including sample preparation and delivery, reaction triggering methods, and large data analysis and interpretation. Early career and established researchers interested in pursuing new techniques are encouraged to attend.

MAX IV in association with LINXS is pleased to announce a symposium on “Scientific achievements through serial crystallography”, marking the start of user operations at the MicroMAX Beamline. The program will take place on September 22-24 at Lund and will feature talks, discussions, and networking with experts in the field—offering insights into emerging directions in structural biology. For registration and further information, visit: MicroMAX symposium webpage.Registration deadline is 1st of September.

The symposium will bring together international leaders in cryo-EM to
discuss advances in cryo-EM technologies, the structural determination of
complex biological systems, and new methods in *in situ* structural
biology, providing sustained momentum for the field's development.

The course is aimed at early-career researchers and facility staff with experience in cryo-EM who are interested in expanding their practical and theoretical knowledge of cryo-FIB/SEM and cryo-ET. The program includes focused lectures and intensive hands-on sessions covering:
 

• Sample vitrification and lamella thinningÂ
• Plasma FIB milling and cryo-lift-outÂ
• Tomographic data acquisition and analysis

The TR+ workshop will provide exciting insight into the broad range of synchrotron-based techniques available at MAX IV to investigate dynamics on a variety of length scales and timescales in biomolecules using X-ray spectroscopy, scattering, serial crystallography, and combined methods.

This workshop will focus on the practical considerations in performing time-resolved synchrotron studies including sample preparation and delivery, reaction triggering methods, and large data analysis and interpretation. Early career and established researchers interested in pursuing new techniques are encouraged to attend.

The Western New York Structural Biology Collaborative is a network
of researchers with the common goal of fostering scientific community and
collaboration within our region. Our meeting serves as a platform to build
connectivity, leverage our collective intellectual and technical resources,
and promote structural biology among the broader scientific community.

This 5-day course is largely aimed at structural biologists with EM maps suitable for modelling building and refinement. This course will host some of the leading software developers and provide ample contact time to allow delegates to discuss their data in detail alongside traditional lectures and tutorials. This is a comprehensive course for EM model building covering advanced use of LocScale, ModelAngelo, Buccaneer, findMySequence-checkMySequence, EM_placement, Coot/Moorhen, TEMPy-REFF, ISOLDE, Refmac-Servalcat, Privateer, new validation tools and AlphaFold-DB & EMDB/PDBe updates. It will cover all aspects of modelling building including: map optimisation, automated model building, model fitting, medium resolution refinement, high resolution refinement, interactive refinement, validation and deposition.
 
Confirmed speakers/topics

Tom Burnley (CCP-EM) : CCP-EM Doppio
Arjen Jakobi (TU Delft) : LocScale
Sjors Scheres (MRC-LMB) : Relion5 and ModelAngelo
Randy Read (University of Cambridge) : EM-placement
Grzegorz Chojnowski (EMBL) : FindMySequence/CheckMySequence
Maya Topf, Tom Mulvaney and Aaron Sweeney (CSSB Hamburg) : TEMPy-REFF, Chem-EM
Lucrezia Catapano (MRC-LMB), Paul Bond (University of York) and George Coldstream (CCP-EM): Coot / Moorhen
Soon Wen Hoh and Paul Bond (University of York) : Buccaneer/ModelCraft
Rob Nicholls (CCP4/CCP-EM), Martin Mal? (MRC-LMB) and Rangana Warshamanage (CCP-EM) : Refmac/Servalcat
Tristan Croll (AltosLabs) : ISOLDE
Jon Agirre (University of York) : Privateer
Jennifer Fleming (PDBe, EBI) : AlphaFold-DB and 3D-Beacons
Agnel Joseph (CCP-EM) : Model validation
Kyle Morris (EMDB, EBI) : EMDB deposition and validation

This in-person beginners? course is aimed at PhD students and postdoctoral researchers who are new to cryo-EM and plan to incorporate it into their research. The programme will combine core theoretical lectures with practical training in single-particle cryo-EM, covering:

 * Negative stain grid preparation and screening
 * Cryo-EM sample preparation (including sample preparation for time-resolved cryo-EM)
 * Grid screening and data collection using EPU on a Titan Krios microscope
 * Demonstration of single-particle data processing using RELION

2025 Pittsburgh Diffraction Conference (PDC)

Hosted by Brookhaven National Laboratory
October 9â€"12, 2025

On behalf of the Conference Committee, we are delighted to invite you to 82nd annual Pittsburgh Diffraction Conference (PDC). This year’s conference will be held October 9â€"12, 2025 at Brookhaven National Laboratory, on New York’s beautiful Long Island.

The Pittsburgh Diffraction Conference is one of the longest-running scientific meetings in North America focused on the advancement of structural science through diffraction-based methods. Bridging both life sciences and materials sciences, the conference brings together researchers who utilize laboratory-based instruments, X-ray light sources, electron diffraction, and neutron scattering to explore the structure and dynamics of matter. It serves as a vibrant forum for sharing recent scientific breakthroughs, fostering interdisciplinary collaborations, and highlighting innovations across experimental and computational frontiers

This year’s program features a diverse and timely selection of breakout sessions, reflecting key areas of growth in the field. Topics include energy storage, emphasizing structural insights that enable next-generation energy technologies; AI and its applications in the development of emergent materials; novel materials with transformative properties; and the effects of extreme environments on structures, reveling details on dynamic processes and molecular motion that lead to biomolecular functions and a better understanding of complex soft materials.

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Conference Web Page and Registration:Â Â

https://www.bnl.gov/pittsburgh-diffraction-conference/index.phpÂ

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Important dates:

April 21, 2025Â Â Â Â Â Â Â Â General registration opens
July 31, 2025Â Â Â Â Â Â Â Â Deadline to submit an abstract for an oral/poster presentation
September 19, 2025Â Â Â General registration closes

Pre-event workshops:

PDF 101: A Hands on Tutorial to Total Scattering Methods (organizers: Milinda Abeykoon, Daniel Olds)

Hands-on Workshop: Crystal Clear Insights: Mastering Protein Crystallization (organizers: Crissy Traver, Vivian Stojanoff)

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Evening Events:

Brookhaven National Lab facility tour.
Friday, October 10, 2025
https://www.bnl.gov/pittsburgh-diffraction-conference/nsls2tour.php

Banquet Dinner
Danfords Hotel and Marina
25 E Broadway, Port Jefferson, NY 11777
Date: Friday, October 10, 2025, 7-9 p.m.

Awards Dinner
Charles B. Wang Center
100 Nicolls Road, Stony Brook, NY 11794
Date: Saturday, October 11, 2025, 7-9 p.m.

The plenary lectures cover the foundational principles and current state-of-the-art in ultrafast X-ray applications across a broad spectrum of scientific domains:

• Fundamentals of X-ray free-electron lasers

• Theory of x-ray matter interaction

• Atomic and molecular physics

• Ultrafast chemical dynamics

• Condensed matter physics

• Structural biology

• Matter in extreme conditions

The focus talks and technical notes will cover current topics related to ultrafast X-ray sciences:

• Attosecond science

• Coherent diffractive imaging

• X-ray optics

• Detector technologies

• Sample delivery systems

• Quantum simulations