I2PC, as developers of Scipion, has as one of its top priorities the improvement of the functionality that Scipion offers to Cryo-EM Facilities. We will present Scipion and how it is used in several Facilities together with its development Road Map. More importantly, there will be ample time to discuss and present common Facility problems, and hopefully share with others how you are running your Facility.

We are proud to announce the 2018 Icknield Workshop kindly supported by
Instruct. This course is aimed at structural biologists with high-
resolution EM maps ready for / in the process of model building and
refinement. This four day course (1st-4th May) will host some of the
leading software developers and provide ample contact time to allow
delegates to discuss their data in detail alongside traditional lectures
and tutorials. It will cover all aspects of model building including: map
optimisation, docking, automated model building, medium resolution
refinement, high-resolution refinement, interactive refinement, validation
and deposition.

The course will be held at the RAL / Diamond Campus, Harwell, UK, site of
the eBIC national facility. Registration is free, thanks to generous
funding from Instruct, and we will provide food and three nights
accommodation at the Bear Hotel in nearby Wantage (nights of 1st, 2nd and
3rd May). Please note that during the application process you will be asked
if you would like to make an accommodation request - if you would like
accommodation provided for you free of charge please select yes and let us
know which nights you would like. If you do not want accommodation provided
for you please select no. Delegates are asked to meet their own travel
costs. Please see the agenda for full course times.

The course is limited to 20 delegates who will be selected from all
applicants. A maximum of 50 applicants can register interest.

 * Confirmed tutors / topics:

Tristan Croll (Cambridge)
ISOLDE: Interactive model building/real-space refinement based on
interactive molecular dynamics

Kevin Cowtan (York)
Buccaneer: automated model building

Paul Emsley (MRC-LMB Cambridge)
Coot: macromolecular model building, model completion and validation

Arjen Jakobi (Delft)
LocScale: scaling tool using prior model information to improve map
contrast

Oleg Kovalevskiy (Murshudov group, MRC-LMB Cambridge)
Refmac: refinement of high-resolution EM structures

Ardan Patwardhan (EBI)
EMBD: deposition in EMBD

Joerg Schaarschmidt (Bonvin Group, Utrecht)
Powerfit: Fast and sensitive rigid-body fitting into cryo-EM density maps

Maya Topf (Birkbeck)
FlexEM: fitting and refinement of atomic structures guided by cryoEM density

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An intense half-week workshop for gifted graduate students

Taught by internationally recognized Cryo-EM experts, the inaugural workshop gives gifted graduate students an intense overview of the latest innovative methodologies and their application across several fields including cancer and neurodegenerative disease research.

The 2018 Kuo Symposium/Workshop on 3DEM of Cells and Molecules, which will be held at Zhejiang University, Hangzhou, China. Major topics of the Symposium include recent developments in cryoEM sample preparation and data acquisition, advances in cryoEM image analysis and reconstruction, advances in cryoET and in situ structural biology, and correlative and hybrid methods for cellular structural analysis.

The cryoEM meeting and workshop series is named after K.H. Kuo (1923-2006), a prominent Chinese scientist, who is among the pioneers discovered several types of quasicrystals in 1980s. Dr. Kuo was also an important educator and mentor who had fostered a generation of electron microscopists in China, Asia and across the world. Since 2008, the Kuo summer school of electron microscopy has provided numerous opportunities for a new generation of scientists to learn the technique of cryoEM through close interactions with many leading scientists in the field during workshop and symposium.

Workshop and K.H. Kuo Summer School: 24-26 August 2018

2018 Kuo Symposium: 26-29 August 2018

This conference brings together structural biologists from across the pharmaceutical and biotech industry to showcase their cutting-edge research.

Scientific sessions will cover the following topics:
• Cryo-EM
• X-ray crystallography
• Lead discovery using NMR
• Protein design
• Membrane crystallography

Exploring the Capability of Cryo-EM to Provide Insight Beyond Static Structures of Macromolecules

Techniques to be Taught:
• Electron microscope alignment
• Negative stain and cryoEM sample preparation
• Automated Data Acquisition
• Single Particle Analysis
• Tomography data collection &analysis
• Atomic model building and validation

A workshop on the applications of deep learning to problems of interest to cryoEM. These may include particle picking, selection of appropriate 2D classes, decisions on the numbers of 3D maps, segmentation of tomograms, etc.

The goal of this workshop is to bring together machine learning experts and cryoEM practitioners to discuss the use of deep learning methods to applications in cryoEM.

Apply to participate at: https://www.surveymonkey.com/r/ZBTJKFR

The workshop can accommodate a total of 25 participants.

The application deadline is 1 March and a final selection of participants will be made by 16 March.

The workshop is dedicated to Integrative Structural Biology

The main objective of this workshop is to offer a theoretical and practical training in the different techniques used in integrative structural biology (X-ray diffraction, small-angle X-ray scattering, NMR, cryo-electron microscopy, sample preparation for structural biology, biophysical methods to study and characterize macromolecular interactions). The goals are to explain and illustrate, to an audience mainly composed of doctoral students and young researchers, the contributions and limitations of each method with a strong emphasis on their complementarity and future developments.
The official language of the workshop is French but presentations may be given in English, depending on the overall profile of the students. For practicals, English and French speaking groups may be organised.

Deadline for registration: April 9, 2018 (maximum number of participants: 25)

More information on the French Initiative ReNaFoBiS : http://www.renafobis.fr/

Fourth annual symposium

The conference aims to provide a forum to highlight state of the art
developments in computational cryoEM and related themes as well as
showcasing outstanding recent applications. We promote an inclusive,
friendly atmosphere welcoming both old and new to the community. Topics
range from detector developments, image processing, single particle
reconstruction, high resolution model building & validation, machine
learning, tomography and electron diffraction.

 Confirmed speakers include:

Mark Basham (Diamond)
Sacha de Carlo (Dectris)
Ana Casanal (MRC-LMB)
Peter Cherepanov (Crick Institute)
Paul Emsley (MRC-LMB)
Hans-Werner Fink (Zurich University)
Achilleas Frangakis (Goethe University Frankfurt)
Tim Gruene (Paul Scherrer Institut)
Nicola Guerrini (STFC)
Ben Himes (Janelia)
Arjen Jakobi (TU Delft)
Corinne Smith (University of Warwick)
Carlos Oscar Sanchez Sorzano (CSIC Madrid)
Chris Russo (MRC-LMB)
Beata Turonova (EMBL)
Giulia Zanetti (Birkbeck)
Kai Zhang (MRC-LMB)
Xiaodong Zhang (Imperial)

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The course will focus on structural biology using Transmission Electron Microscopy and aims to teach the participants the basic principles and practical aspects of specimen preparation, Image processing and 3D reconstruction in Single Particle Cryo Electron Microscopy (SPCryoEM) and Cellular Tomography. This is a hands-on course, in which theory and practicals are tightly intertwined. There will be practical session to teach sample preparation for Single particle â€"ve stain and cryoEM. The topics covered will suit both the new entrants to the field as well as those who wants to acquire an in-depth understanding of the fundamental principles and practical aspects.

Applications are invited from PhD students, Post Docs and Researchers (Faculties/PI’s and protein crystallographers) who wish to acquire knowledge in SPCryoEM and Cellular Tomography. Applicants from all over the world are encouraged to apply.

The basic format of the course will be theoretical lectures in the mornings followed by hands on practical session on specimen preparation and image processing on computer workstations in the afternoon. Evenings will be reserved for poster presentations by the participants and research talks by the participants/instructors.

The instructors/speakers for the course will include:

• Tony Crowther (MRC-LMB),
  
• Wah Chiu (Stanford University),
  
• Jack Johnson (TSRI),
  
• Marin van Heel (Leiden University),
  
• Edward Morris (ICR),
  
• Paula da Fonseca (MRC-LMB),
  
• Peter Rosenthal (TFCI),
  
• Carsten Sachse (EMBL Heidelberg),
  
• Sara Sandin (NTU),
  
• Ardan Patwardhan (EMBL-EBI),
  
• Maya Topf (Birkbeck),
  
• Srinivasan N (IISc),
  
• Tanmay Bharath (Dunn School of Pathology),
  
• Agnel Praveen (Birkbeck),
  
• Tanveer Hussain (IISc),
  
• Sonja Welsh (FEI - part of Thermo Fisher Scientific),
• Jayati Sengupta (IICB),
  
• Manidipa Banerjee (IIT Delhi),
  
• Ramanathan Natesh (IISER Thiruvananthapuram),
  
• Vinothkumar KR(NCBS),
  
• Partha Pratim Datta (IISER Kolkota),
  
• Somnath Dutta (IISc).