This six-days course is intended for PhD students and post-docs who expect to be using modern structural methods for future studies.

Registration deadline is May 2, 2022.

04.00 PM PARIS time

Topic : Watching molecules dancing in the cell. 
After a short journey through the evolution of structural biology and the present state of the art of crystallography and cryo-EM, 
we will show how the combination of optical methods and cryo-tomography open the door to the cell at atomic level. 

Webinar Speaker : 

Dino Moras (UNISTRA, CNRS, IGBMC) 

• The basics of the Hermes interface, the CCDC's 3D visualiser for proteins
• Step-by-step basics of GOLD
• Where to get started with your docking simulation and how to run a standard protein-ligand dock with GOLD
• How to identify the correct binding modes reliably and with confidence

8:00-9:30 AM (Pacific Time)
 

SPEAKERS:
Dr. Steven J. Ludtke, Charles C. Bell Professor at Baylor College of Medicine
Talk Title: Compositional and conformational variability in CryoEM and CryoET: structural biology in context
 

Dr. Wolfgang Jaeger, Professor at University of Kiel
Talk Title: Advanced and in situ TEM for the development of high-efficiency solar cells
 
https://stanford.zoom.us/webinar/register/WN_VWKdNnibQ7ir7-BbtM2bXg 

Date: 30^th of March, 4.30 PM CET

Speakers:

Prof. Hans Florian Zeilhofer, Delegate for Innovation, University of Basel

Dr. Christoph Boss, Head of Drug Discovery Chemistry, Idorsia

Prof. Michael Hennig, CEO, leadXpro AG
Dr. Mihaela Pop, Chief Scientific Officer TeraCrystal
Dr. Bernd Hinrichsen, Head of Electron Microscopy BASF
Prof. Paulina Dominiak, Group head, University of Warsaw
Dr. Michael Kaufmann, Partner, BOHEST intellectual property
Prof. Christian Lehmann, Group head, MPI für Kohlenforschung

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Sessions start 12:00 pm GMT+1 (British Summer Time)

Event Outline

• A two-day academic symposium including prestigious talks and poster sessions
• Nobel Prize winner Richard Henderson will give the plenary public lecture “Zooming in on the molecules of life”.

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The conference aims to provide a forum to highlight state of the art developments in computational cryoEM and related themes as well as showcasing outstanding recent biological applications. We aim to promote an inclusive, friendly atmosphere welcoming both old and new to the community. Topics include instrument technology, sample preparation, image processing, single particle reconstruction, tomography and model building.
 

The schedule will also include the Diamond Light Source biological cryo-imaging user meeting for eBIC & B24.

The keynote lecture will be given by Wolfgang Baumeister.
Confirmed Speakers
Martin Beck (Max Planck Institute of Biophysics, Germany)
Alex DeMarco (Monash University, Australia)
Achilleas Frangakis (Goethe University Frankfurt, Germany)
Dorit Hanein (Institut Pasteur, France)
Janet Iwasa (UU Salt Lake City, USA)
Grant Jensen (Caltech, USA)
Peter Peters (Maastricht University, Netherlands)
Gaia Pigino (Human Technopole, Italy)
Bram Koster (Leiden University Medical Centre, Netherlands)
Wanda Kukulski (University of Bern, Switzerland)
Jun Liu (Yale University, USA)
Julia Mahamid (EMBL, Germany)
David Mastronarde (UC Boulder, USA)
Ohad Medalia (Zuerich University, Switzerland)
Daniela Nicastro (UT Southwestern, USA)
Martin Pilhofer (ETH, Switzerland)
Joergen Plitzko (Max Planck Institute of Biochemistry, Germany)
Stefan Raunser (Max Planck Institute of Molecular Physiology, Germany)
Sharon Wolf (Weizmann Institute, Israel)
Elizabeth Wright (UW Madison, USA)
Peijun Zhang (Oxford University & Diamond, UK)

MAX IV, the pioneer in multi-bend achromat synchrotron technology, would like to invite the synchrotron and free electron laser (FEL) life science community to Lund to discuss the latest and hottest developments in the field at the 14th BSR.

By 2022, several other synchrotron facilities will also have upgraded their sources or have defined upgrade plans and the organizers feel it would be opportune to discuss and highlight the latest developments and the possibilities for biological experiments at the next generation of synchrotrons and FELS.

Main themes

• Membranes: lipids and proteins
• Synchrotrons and FELS for pandemic research
• Hybrid or correlative approaches to complex biology
• Scientific computing for life sciences
• Coherence approaches
• Environmental and bioeconomy/industrial and pharma
• Tissues and cells
• Dynamics and ultrafast science

WEDNESDAY, DECEMBER 15, 13:30 (EST or New York City Time Zone)

The Topp Lab's integrated phenomics approach to uncovering the molecular basis of root traits in multiple crop species will be presented. We specialize in developing root and rhizosphere imaging technologies and analytics: in particular X-ray CT, positron emission tomography, and statistical and deep learning methods. By integrating these efforts with natural variation and genomics, we focus on the development of new crop and cover crop varieties with root systems tailored to the local environment that enhance drought tolerance, efficient nutrient uptake, and ecosystem services towards sustainable agriculture goals.

The 15th webinar in the series, which will be hosted by Instruct Portugal on 14th December 2021, 11:00 - 12:30 CET

The upcoming webinar will feature talks on the application of structural biology methods to better understand key aspects of protein complexes structure and function. The webinar speakers will discuss new drug targets for diseases, with a focus on Mycobacterium tuberculosis. Additional topics include structural biology techniques with Mass Spectrometry and Cryo-EM.

 * Talk 1: Exploring a new drug target against Mycobacterium tuberculosis

Speaker: Hugo Fraga
 * Talk 2: Breaking the limits of native MS with MRMS
Speaker: Carlos Cordeiro
 * Talk 3: Catching up with the CryoEM Resolution Revolution

Speaker: Pedro Matias

Moderator: Maria Arménia Carrondo, Universidade Nova de Lisboa

All timings are in IST
If we are unable to accommodate you on live session, there will be

a link sent to you for lecture videos on demand after the meeting.

 

The first /StruBioMol Conference: Structural biology for medicine and biotechnology is organised by Interreg SK-AT  partnership “StruBioMol”
 
 

The conference will be in a *digital format*, on the *6th December 
2021, starting at 9 o'clock.*

*Registrations* are available till 5th December at: 
https://www.eventbrite.com/e/structural-biology-for-medicine-and-biotechnology-tickets-217640437407
 

08:55 - 09:00 Welcome and Introduction

Kristina Djinovic Carugo, Eva Kutejova

09:00 - 09:40RNA aptamers in amyotrophic lateral sclerosis

Annalisa Pastore (The Crick/ESRF)

09:40 - 10:20 Structure-aided development of ligands targeting human 
prostate-specific membrane antigen

Cyril Bařinka(Institute of Biotechnology, The Czech Academy of Sciences)

10:20 - 10:30Coffee break

10:30 - 11:10Structural basis of inhibition of the pioneer transcription 
factor NF-Y

Marco Nardini(Dept. of Biosciences, University of Milano)

11:10 - 11:50Structural biology of plant diseases and potential applications

MarjetaPodobnik(National Institute of Chemistry, Slovenia)

11:50 - 12:30 Lunch

12:30 -Â 13:10 To be or not to be? The presence of non-B-DNA structures 
in genomic DNA

                          VáclavBrázda(Institute of Biophysics, Czech 
Academy of Sciences)

13:10 - 13:50Molecular Interactions of Alginates in Food Ingredients and 
in the Gut

BirteSvensson(Technical University of Denmark)

13:50 - 14:00Coffee break

14:00 - 14:40 Targeting protein-protein interactions in Mixed-linage 
leukemia

Václav Veverka(Institute of Organic Chemistry and Biochemistry, The 
Czech Academy of Sciences)

14:40 - 15:20Active site and allosteric inhibitors of SARS-CoV-2 main 
protease

Sebastian Günther â€" TBC(DESY, Hamburg)

15:20 - 16:00NMR spectroscopy in biomedicine and structure-based drug design

Robert Konrat(DeptStructComputBiol, MPL, Universityof Vienna)

If you have any questions, please do not hesitate to contact Vladimir 
Pevala  and/or jörg Böckelmann 
.

Professor Peter Stockley

University of Leeds

WEDNESDAY, NOVEMBER 17, 13:30 (EST; NY time)
 

Abstract:

Many viruses that package single-stranded RNA genomes into a protective infectious virion regulate their assembly by sequence-specific RNA-coat protein (CP) contacts. These occur at defined sequences/motifs (PSs) dispersed across viral genomes (gRNAs), but vary in sequence and hence affinity for their cognate CPs, creating a preferred assembly pathway. Uniquely X-ray foot-printing has allowed us detect these CP-gRNA contacts within infectious particles. Similar PS-like contacts occur within a self-assembling enzyme cage artificially evolved so that it packages its mRNA more efficiently. This implies that PS-mediated assembly is relevant far beyond virology.

For our major model virus, foot-printing reveals that most PSs dissociate post-assembly facilitating genome release for the next round of infection. Here, and potentially in all viruses, molecular frustration appears to be a major driving force regulating the life cycle.

When: Dec 8, 2021 04:00 PM Paris 

Webinar Speaker Dr. Wladek Minor (Harrison Distinguished Professor, Department of Molecular Physiology and Biological Physics, University of Virginia, USA) 

Topic: Structural Biology Response to Biomedical Threats
 
Register in advance for this webinar: 
https://us06web.zoom.us/webinar/register/WN_KnjC1dDBRZG4r8F6hQ_-VQ 

After registering, you will receive a confirmation email containing information about joining the webinar. 

The 9th Annual International Conference will be chaired by Tonya Kuhl, UC-Davis, and Thomas Grant, UB. The meeting is currently virtual but we are investigating the potential for a hybrid format.

Registration is now open.

 

Robert Buecker (CSSB-Hamburg)
Sarah Bowman (HWI)

Henry Chapman (DESY)

Ahmad Hozzeinedeh (UWM)

Hyotcheryl Ihee (KAIST)

Richard Kirian (ASU)

J. Mia Lahey-Rudolph (Lubeck)

Filipe Maia (PSI)

Valerio Mariani ((SLAC)

Fivos Perakis (Stockholm)

Megan Shelby (LLNL)

Jason Stagno (NIH)

Pablo Villaneuva-Perez (Lund)

Nadia Zatsepin (LaTrobe)

Jian-Min Zuo (U of IL-Urbana Champagne)