Hands-on workshop with lectures, practical tutorials and plenty of time for problems-solving with X-ray diffraction data.
All-virtual format, including remote data collection at Diamond synchrotron.

Main Topics:

• data collection (remotely @ Diamond synchrotron, measuring students’ crystals)

• data processing

• phasing and structure determination

• model refinement and validation

25 participants will be selected, prioritizing advanced PhD students, postdocs and young researchers.

No registration fee, please look in the www site for details on application procedures.

Participants will have the opportunity to collect data from their own crystals at Diamond Light Source synchrotron via remote access, with the assistance of Diamond staff.

The workshop will be virtual considering the pandemics constraints. It will combine excellent lectures with hands-on problem-solving sessions.

Tutorials of state-of-the-art software will include XDS, Dials, Phaser, ShelX, Coot, Refmac, Buster-TNT, PISA, among others.

Since the workshop is virtual additional participants may elect to attend lectures only. If you wish to do this please complete the registration form and indicate that this is your choice.

Invited speakers and tutors:

• Rafael Junqueira Borges (Instituto de Biociências UNESP, Botucatu, Brazil)

• Kevin Cowtan (University of York, UK)

• Eleanor Dodson (University of York, UK)

• Paul Emsley (Laboratory of Molecular Biology MRC, Cambridge, UK)

• Elspeth Garman (University of Oxford, UK)

• Richard Garratt (Instituto de Física de São Carlos, Brazil)

• Beatriz Guimarāes (Instituto Carlos Chagas Fiocruz, Curitiba, Brazil)

• Marin van Heel (Lab. Nacional de Nanotecnologia CNPEM, Campinas, Brazil)

• Ronan Keegan (STFC Rutherford Appleton Lab â€" CCP4, Didcot, UK)

• Eugene Krissinel (STFC Rutherford Appleton Lab â€" CCP4, Didcot, UK)

• Andrey Lebedev (STFC Rutherford Appleton Lab â€" CCP4, Didcot, UK)

• Natalia Lisa (Instituto de Biología Molecular y Celular, Rosario, Argentina)

• Garib Murshudov (Laboratory of Molecular Biology MRC, Cambridge, UK)

• James Parkhurst (Diamond Light Source, Didcot, UK)

• Randy Read (University of Cambridge, UK)

• Silvia Russi (Stanford Synchrotron Radiation Lightsource, USA)

• Nukri Sanishvili (Argonne National Laboratory, Chicago, USA)

• Isabel Usón (Instituto de Biología Molecular de Barcelona, Spain)

• Clemens Vonrhein (Global Phasing Ltd, Cambridge, UK)

Organizers:

Nicole Larrieux, Clinical Biochemist. Institut Pasteur de Montevideo, Uruguay

Kyle Stevenson, DPhil. CCP4, STFC Rutherford Appleton Laboratory, United Kingdom

Alejandro Buschiazzo, PhD. Institut Pasteur de Montevideo, Uruguay

This Workshop is supported by the Collaborative Computational Project Nº4 (CCP4, UK) & Science and Technology Facilities Council (UK); the Centro de Biologia Estructural del Mercosur (CeBEM); and the Programa Iberoamericano de Ciencia y Tecnologia para el Desarrollo (CYTED) through de MICROBES consortium.Â

We anticipate holding the course in person as long as the pandemic situation continues to improve. Appropriate COVID-19 precautions will be followed to ensure the safety of all participants. Everyone will be required to provide documentary proof of a prior FDA or EMA approved vaccine.

Â

This immersive course is an outstanding place to learn both the theoretical and practical aspects of Macromolecular Crystallography because of the extensive lectures from world-renowned teachers, which are combined with hands-on experiments. This 2021 course will be lead by Jim Pflugrath (Rigaku, ret.), Tassos Perrakis (NKI), Paul Adams (LBL), Janet Newman (CSIRO; likely remote)), Tom Peat (CSIRO; likely remote) and an All-Star cast of lecturers. Attendees can expect to participate in a course that is unparalleled in the world, with experts each devoting several days to teaching the fundamentals, theory and practical considerations of crystallographic structure solution.

Topics to be covered include

• Basic diffraction theory
  
• Crystallization (proteins, nucleic acids, complexes and membrane proteins)
  
• Synchrotron X-ray sources and optics
  
• Data collection and processing
  
• Structure solution by experimental phasing methods (SAD, MAD, MIR, and others) and molecular replacement
  
• Electron density maps improvement
  
• Model building and refinement
  
• Structure validation
  
• Coordinate deposition
  
• Structure presentation

The course is limited to 16 participants due to the very hands-on nature of the experiments and the intimate seminar room and laboratory settings. Please check the above web link for more details. In particular, please note the information about fellowships, scholarships, and stipends that are available. It is often possible for applicants to receive some level of support to help offset the course fee.

This school will be a fully online event organized in Budapest, Hungary

Extended Standard registration deadline
30 June 2021

Student under 35 years: EUR 240
Participant above 35 years: EUR 290
Non-Academic: EUR 390

Â

Â

Simons Electron Microscopy Center
New York Structural Biology Center, New York, NY

Over the past 20 years, data collection for cryoEM has become highly automated. However, most data collection sessions still require operator oversight to obtain the highest quality data. This goal of this workshop is to address next generation data collection strategies that integrate machine learning and real-time processing to reduce or eliminate the need for operator intervention. We invite applications to participate in this workshop which will take place in-person in New York, NY.
 

The workshop can accommodate a total of 25 participants.

The application deadline is 1 September 2021. A final selection of participants will be made by 15 September 2021.
 

To register please visit 
 https://www.surveymonkey.com/r/RGDHFK7

Thursday 24th June 2021 at 10am EST.

Â

Due to the expected large audience, please register online in advance.

Â

Structural Biology to enhance high impact research in health and disease

Â

Main Topics:
· data collection (remotely @ Diamond synchrotron);
· data processing;
· phasing and structure determination;
· model refinement and validation.

25 participants will be selected, prioritizing advanced PhD students, postdocs and young researchers. No registration fee, please look in the www site for details on application procedures.
Participants will have the opportunity to collect data from their own crystals at Diamond Light Source synchrotron via remote access, with the assistance of Diamond staff.
The workshop will be virtual considering the pandemics constraints. It will combine excellent lectures with hands-on problem-solving sessions. Tutorials of state-of-the-art software will include XDS, Dials, Phaser, ShelX, Coot, Refmac, Buster-TNT, PISA, among others.
Since the workshop is virtual additional participants may elect to attend lectures only. If you wish to do this please complete the registration form and indicate that this is your choice.

Invited speakers and tutors :
• Rafael Junqueira Borges (Instituto de Biociências UNESP, Botucatu, Brazil)
• Kevin Cowtan (University of York, UK)
• Eleanor Dodson (University of York, UK)
• Paul Emsley (Laboratory of Molecular Biology MRC, Cambridge, UK)
• Elspeth Garman (University of Oxford, UK)
• Beatriz Guimarāes (Instituto Carlos Chagas Fiocruz, Curitiba, Brazil)
• Marin van Heel (Lab. Nacional de Nanotecnologia CNPEM, Campinas, Brazil)
• Ronan Keegan (STFC Rutherford Appleton Lab â€" CCP4, Didcot, UK)
• Eugene Krissinel (STFC Rutherford Appleton Lab â€" CCP4, Didcot, UK)
• Andrey Lebedev (STFC Rutherford Appleton Lab â€" CCP4, Didcot, UK)
• Natalia Lisa (Instituto de Biología Molecular y Celular, Rosario, Argentina)
• Joāo Muniz (Instituto de Física de São Carlos, Brazil)
• Garib Murshudov (Laboratory of Molecular Biology MRC, Cambridge, UK)
• James Parkhurst (Diamond Light Source, Didcot, UK)
• Randy Read (University of Cambridge, UK)
• Silvia Russi (Stanford Synchrotron Radiation Lightsource, USA)
• Nukri Sanishvili (Argonne National Laboratory, Chicago, USA)
• Isabel Usón (Instituto de Biología Molecular de Barcelona, Spain)
• Clemens Vonrhein (Global Phasing Ltd, Cambridge, UK)

Organizers:
Nicole Larrieux, Clinical Biochemist. Institut Pasteur de Montevideo, Uruguay
Kyle Stevenson, DPhil. CCP4, STFC Rutherford Appleton Laboratory, United Kingdom
Alejandro Buschiazzo, PhD. Institut Pasteur de Montevideo, Uruguay

The application deadline is June 30, 2021.

This webinar is about the FragMAX facility for crystallographic fragment screening at MAX IV Laboratory to be held June 17th, 14:00 â€" 15:00 (CEST)
 

Agenda:

 * Introduction to crystal-based fragment screening
 * FragMAX components and design:
 * Crystal preparation workflow
 * Data collection at BioMAX
 * Large-scale data processing (including FragMAXapp demo)
 * Prerequisites & crystal checklist
 * Access modes for academia and industry
 * Current developments

 

Please register below and you will receive your ZOOM link shortly:

https://indico.maxiv.lu.se/e/FragMAX_webinar

June 7, 2021, 8:00 - 9:30 a.m. (PDT).

Prof. Wah Chiu, Stanford University, "Cryo-EM Redefines the Boundaries of Structural Biology"

Prof. Lena F. Kourkoutis, Cornell University, "Atomic-resolution Cryo-EM for Quantum Science"
 
Please register: Â https://stanford.zoom.us/webinar/register/WN_-W_CXuUKQs-3NE96ydJi8A

The remote practical course covers principles, differences and applications of macromolecular crystallography using X-rays, neutrons and electrons. The course is targeted to PhD students and postdocs whose research project focuses on solving structures using crystallography.

Â

Â

Teachers:

Eugene Krissinel (CCP4, UK)

Andrey Lebedev (CCP4, UK)

Esko Oksanen (ESS, Sweden)

Edward Daniel (University of Oulu, Finland)

Bernhard Rupp (Medical University Innsbruck, Austria)

Andrea Thorn and Gianluca Santoni are co-chairing a session at IUCr meeting 2021 
entitled "Structural biology of coronaviruses" on the 16th of August.
The subject of the session are structural and functional insights about 
the life cycle and virus-host interaction of SARS-CoV-2 and other 
coronaviruses with a particular view to integrative uses of 
crystallography in connection with other methods.

The Partnership for Structural Biology (PSB), an alliance of research institutes (EMBL, ESRF, IBS and ILL) located in Grenoble, France, is pleased to announce that the PSB Symposium "Frontiers in Bioimaging" will take place on 1-2 July 2021. The meeting will be held remotely on a virtual event platform over two afternoons, and will include a series of invited and selected talks, interactive virtual posters, and interactive virtual lounges.
 

You are invited to submit an abstract for a poster and/or an oral presentation (short talks of 10 minutes).

Submission deadline on 23 May 2021. The number of posters is limited to 50, and best poster prizes (150 euros each) will be awarded.

Registration is free, deadline on 27 June 2021
 

ReNaFoBiS/FRISBI Webinar Series Serial Femtosecond Crystallography @ XFELs; current and future prospects for structural biology.

Â

May 12, 2021 04:00 PM (CET, France) 
Jacques-Philippe Colletier (PhD, DR CNRS, Serial Nano-Crystallography team (SNaX), IBS, Grenoble, France) 

Lectures: June 21 - June 25, 2021

Tutorials: June 28 - 30, 2021

2:00 pm - 5:30 pm EST

Registration (free) is now open and will close May 14, 2021: https://conference.sns.gov/event/291/registrations/
 

This online course is designed for graduate students, post-doctoral researchers and faculty with knowledge of structure and function of biological macromolecules but with limited to no experience with neutron sciences. The course will cover the basics of deuterium labeling, small angle neutron scattering, neutron reflectometry, neutron spectroscopy, neutron imaging and neutron crystallography. Lectures will cover basic concepts, sample preparation, instrumentation and applications. Data collection and processing will be discussed in tutorials.

This is the 1st Workshop from LINXS Membrane Protein Working Group
 

AIM

The aim is to provide expert overview about different platforms for
recombinant protein productions and purification strategies for
crystallography techniques. Overcoming low yield expression, misfolded
proteins and difficulties in purifying stable functional proteins are among
the most common bottlenecks delaying structural characterization. We invite
scientists to introduce their best practices in these subjects in order to
provide greater knowledge and knowledge transfer on how best to deal with
these challenges.
 

CONTRIBUTED TALKS

We hope to engage the attendance from PhD students and postdocs from a
range of disciplines, as well as more senior researchers. We are
encouraging participants, and especially PhD students, to consider
presenting their research in a contributed talk (call for abstracts) and
also to promote lively discussions.

CONTENT

*Day 1:*

 - Workshop aims and scope of the general problem
 - Membrane Protein Expression
 - Comparison of different expression systems
 - Success stories vs trouble-shooting problem areas, trial and error

 - Confirmed speakers:
 *Roslyn Bill* (Aston University) - *Recombinant membrane protein
 production in microbial hosts*
 *David Drew* (Stockholm University) - TBA
 *Joseph Lyons *(Aarhus University) - TBA

*Day 2:*

 - Sample Preparation, Quality Control
 - Membrane solubilization and other preparation methods

Confirmed speakers:
*Arjan Snijder* (AstraZeneca) - *Membrane protein purification and
application in drug discovery*
*Christopher G. Tate* (Cambridge University) - *Whipping GPCRs into shape
for structure determination*

In the autumn the plan is to continue further on topics about membrane
protein crystallization techniques, Cryo-EM or neutron structures,
scattering techniques and well-diffracting crystals.

Please find *Registration* and Timetable (will be updated with abstracts)
here: https://indico.linxs.lu.se/event/219/

By Denis Zeyer (CEO NovAliX ), PhD 
April 21, 2021 08:00 PM Paris

The First Regional Structural Biology meeting for Balkans and the South-East Mediterranean
area” is jointly organized by iNEXT-Discovery partners NHRF and NKI and is to be
held online on Friday afternoon, May 14th, 2021.
 
 

The aim of the meeting is to:

- increase awareness of EU-wide iNEXT-Discovery and Instruct-ERIC
structural biology services

- emphasize on possibilities for remote access

- broaden the structural biology user community

- strengthen awareness and cooperation between European stakeholders
An overview of structural biology research in the European Research Area will
be presented by Prof. Anastassis Perrakis, Prof. Sir David Stuart, Prof.
Harald Schwalbe, Dr Andreas Holtel and Prof. Yannis Ioannidis followed by *open
discussion to stimulate the engagement of key stakeholders in Structural
Biology at Regional level*. The target group of the meeting is scientists
from academia and industry, research administrators and decision-makers
from Balkans and Southern Mediterranean countries.

Please find more information on the event and the agenda at the following
link:

https://inext-discovery.eu/events/first-regional-structural-biology-meeting-balkans-and-the-south-east-mediterranean/

or register at
https://zoom.us/meeting/register/tJAsd-GhpzgjE9db7CXW_hlcqIAB88t4Crzc
 

This meeting is supported by iNEXT-Discovery (grant no. 871037) an EU
H2020 project for stimulating the use of structural biology research in
Europe.

 

Phenix User Workshop on 14th of April at 4-9pm PDT.* These times will work best for
researchers in Asia and Australasia.
 

he format of the workshop will be demos of the use of Phenix programs
combined with slides to explain the theory. We expect an interactive
meeting where attendees can ask questions for the Phenix team to answer.

The workshop will cover aspects of macromolecular crystallography
in Phenix, with the final emphasis based on the applicants’ research
interests.
 

To apply please fill out this form
. We will make every effort to
accommodate all applicants, but may need to defer some requests to a
future workshop if demand is high. We are hoping this workshop will be a
success, in which case we plan to host more in the future.

*14 APR *

 - 3.45pm - Start of Zoom session (for people to debug any issues)
 - 4.00pm - Pavel Afonine - Real Space Refine
 - 5.15pm - Nigel Moriarty - Ligands and Restraints
 - 6.00pm - Jane Richardson - Validation
 - 7.00pm - Question/Answer session