The conference aims to provide a forum to highlight state-of-the-art developments in computational cryoEM and related themes, as well as showcasing outstanding recent biological applications. We aim to promote an inclusive, friendly atmosphere, welcoming those both old and new to the community. Topics include instrument technology, sample preparation, image processing, single particle reconstruction, tomography and model building.
 

The meeting includes the Diamond Light Source Biological Cryo-Imaging User Meeting for eBIC & B24 and the venue will also host the Karen M. Davies Memorial Symposium in memory of our dearly missed friend and colleague Karen.

The course will take place on 2?6 March 2026 in a hybrid format, with online lectures followed by in-person, hands-on training across our partner cryo-EM facilities, including ABSL (University of Leeds), eBIC (Diamond Light Source), Birkbeck College (University of London), the Midlands Regional Cryo-EM Facility (University of Leicester), and the Scottish Centre for Macromolecular Imaging (University of Glasgow).
 

It is aimed at postgraduate students and postdoctoral researchers who are new to the field and plan to use cryo-EM single-particle analysis or cryo-ET in their research. Financial support for travel and accommodation is available.

December 8, 2025, Monday, 8-9:30am (PST)

 
Prof. David Eisenberg (UCLA)

Talk Title: CryoEM-based discovery of small molecules that disassemble stable pathological fibrils associated with the onset of Alzheimer's and Parkinson's diseases
and

Prof. Wu Zhou (UCAS)

Talk Title: Vibrational EELS with Single-Atom Sensitivity: from isotope mapping to probing electron-phonon interactions

To be held at Human Technopole in Milan, Italy. The workshop is co-organised by Instruct-ERIC, Thermofisher, Human Technopole, and the EC-funded project IMAGINE.
 

Why attend?

 * The workshop is aimed specifically at scientists, facility managers, and computing staff involved in high-end cryo-EM operations and provides a platform to exchange practical insights and workflow innovations.

 * The programme features invited presentations, round-table discussions, a live demo of the Arctis from the Max Planck Institute of Biochemistry and a tour of the Human Technopole facilities.

 * Key themes include the EU-funded IMAGINE project, emerging technologies and workflows in TEM & dual-beam techniques, and best practices in facility management.

 

Registration Deadline: 15 January 2026

12:00 PM Eastern (US, Canada) / 5:00 PM GMT (UK)
 

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling high-resolution visualization of dynamic biomolecular assemblies. However, a central challenge remains: developing robust computational methods to model different forms of structural heterogeneity?including continuous motions, discrete states, and compositional variations and to accurately estimate population distributions.

To encourage the development and benchmarking of heterogeneous reconstruction algorithms and workflows, we invite the cryo-EM community to analyze three new curated experimental and synthetic datasets:

1. Compositional Heterogeneity
2. Conformational Heterogeneity
3. Pose Entanglement

Please join us for a webinar where we will introduce this year's challenge.
Submissions close on June 1, 2026.

Please share this with others who may be interested. We hope you?ll join us for this year?s challenge!

This conference brings together researchers and software developers for in-depth, open discussions on emerging image analysis methods and algorithmic advances addressing challenging biological questions. Each session is designed to foster lively interaction, with plenty of time for questions and exchange of ideas.

The 2026 program will feature an exciting lineup of speakers and sessions, including:

• Compositional and conformational variability in vitro and in situÂ
• Automation, modeling, and validation in cryo-EM and cryo-ETÂ
• Tomogram segmentation and interpretationÂ
• Round-table discussion on Deep Learning and Community Innovation (Kaggle/SHREC)Â
• Keynote Address: Professor Bridget Carragher (CZII)Â
• A session of selected short talks from poster presenters. Poster abstracts are due by February 15, 2026, to be included in the program and considered for short talks.

Thursday, October 30, 2025 at 9 AM pacific / 12 PM eastern time

This 1-week course will step through each stage of the SPA workflow (sample preparation, data acquisition and computational processing). The mornings will include lectures and stimulating round table discussions. The afternoons will have hands-on practicals to reinforce the concepts and topics covered earlier in the day.
 

The regular application deadline is December 15, 2025 by 5pm. Accepted applicants will be informed in early January 2026.

This workshop will bring together leading experts to share the latest best practices, tools, and techniques in cryoEM model building, refinement, visualization, validation, and deposition.

Confirmed speakers include:

 * Paul Emsley & Lucrezia Catapano (MRC)
 * Rachael Kretsch (Stanford University)
 * Stephanie Wankowicz (Vanderbilt University)
 * Tom Goddard (UCSF)
 * Tristan Kroll (Altos Labs)
 * Nigel Moriarty & Oleg Sobolev (LBNL)
 * Jane Richardson (Duke University)
 * Greg Pintilie (Stanford University)
 * Stephen Burley & Justin Flatt (RCSB Protein Data Bank)

The program will feature expert-led talks and live demonstrations on Coot, Phenix, ISOLDE, ChimeraX, and other software tools, along with discussions on structure validation and deposition guidance. All sessions will be recorded and made available on the S2C2 website after the event for participants to review or catch up on missed content.

Jointly organized by the Institute of Science and Technology Austria (ISTA) and the Vienna Biocenter (VBC).
 
Speakers:

Nikolaus Grigorieff | University of Massachusetts Chan Medical School, USA
Ariane Briegel | Institut Pasteur, France
Beata Turonova | Max-Planck Institute of Biophysics, Germany
Maya Topf | University Medical Center Hamburg-Eppendorf, Germany
Florian Wilfling | Max-Planck Institute of Biophysics, Germany
Manuela Hospenthal | ETH Zurich, Switzerland
Carina Oliveira Mann | Technical University of Munich, Germany
Basil Greber | Institute of Cancer Research, UK
Sven Klumpe | Research Institute of Molecular Pathology (IMP) Vienna, Austria
Sebastian Glatt | University of Veterinary Medicine Vienna, Austria

The course is aimed at early-career researchers and facility staff with experience in cryo-EM who are interested in expanding their practical and theoretical knowledge of cryo-FIB/SEM and cryo-ET. The program includes focused lectures and intensive hands-on sessions covering:  

• Sample vitrification and lamella thinning
• Plasma FIB milling and cryo-lift-out
• Tomographic data acquisition and analysis

This intensive workshop combines state-of-the-art lectures and hands-on tutorials led primarily by expert members of the CCP4 and CCPEM communities, alongside Latin American researchers currently working in protein crystallography and cryo-electron microscopy. Participants will gain deep insight into the theory and extensive experience in data processing for these techniques, offering a unique opportunity to master essential tools and methods in macromolecular structure determination.

Hosted by the Stanford-SLAC CryoEM Center (S2C2), this workshop will bring together leading experts to share the latest best practices, tools, and techniques in cryoEM model building, refinement, visualization, validation, and deposition.
Confirmed speakers include:

Paul Emsley & Lucrezia Catapano (MRC)
•
Dari Kimanius (Chan Zuckerberg Institute for Advanced Biological Imaging)
•
Rachael Kretsch (Stanford University)
•
Stephanie Wankowicz (Vanderbilt University)
•
Tom Goddard (UCSF)
•
Tristan Kroll (Altos Labs)
•
Nigel Moriarty & Oleg Sobolev (LBNL)
•
Jane Richardson (Duke University)
•
Greg Pintilie (Stanford University)
•
Stephen Burley & Justin Flatt (RCSB Protein Data Bank)

The program will feature expert-led talks and live demonstrations on Coot, Phenix, ModelAngelo, ISOLDE, ChimeraX, and other software tools, along with discussions on structure validation and deposition guidance. All sessions will be recorded and made available on the S2C2 website after the event for participants to review or catch up on missed content.

https://s2c2.slac.stanford.edu/form/stanford-slac-cryoem-center-mode

2025 Pittsburgh Diffraction Conference (PDC)

Hosted by Brookhaven National Laboratory
October 9–12, 2025

On behalf of the Conference Committee, we are delighted to invite you to 82nd annual Pittsburgh Diffraction Conference (PDC). This year’s conference will be held October 9–12, 2025 at Brookhaven National Laboratory, on New York’s beautiful Long Island.
 

The Pittsburgh Diffraction Conference is one of the longest-running scientific meetings in North America focused on the advancement of structural science through diffraction-based methods. Bridging both life sciences and materials sciences, the conference brings together researchers who utilize laboratory-based instruments, X-ray light sources, electron diffraction, and neutron scattering to explore the structure and dynamics of matter. It serves as a vibrant forum for sharing recent scientific breakthroughs, fostering interdisciplinary collaborations, and highlighting innovations across experimental and computational frontiers

This year’s program features a diverse and timely selection of breakout sessions, reflecting key areas of growth in the field. Topics include energy storage, emphasizing structural insights that enable next-generation energy technologies; AI and its applications in the development of emergent materials; novel materials with transformative properties; and the effects of extreme environments on structures, reveling details on dynamic processes and molecular motion that lead to biomolecular functions and a better understanding of complex soft materials.

Conference Web Page and Registration:  

https://www.bnl.gov/pittsburgh-diffraction-conference/index.php 

Important dates:

April 21, 2025               General registration opens
July 31, 2025                Deadline to submit an abstract for an oral/poster presentation
September 19, 2025      General registration closes

Pre-event workshops:

PDF 101: A Hands on Tutorial to Total Scattering Methods (organizers: Milinda Abeykoon, Daniel Olds)

Hands-on Workshop: Crystal Clear Insights: Mastering Protein Crystallization (organizers: Crissy Traver, Vivian Stojanoff)

Evening Events:

Brookhaven National Lab facility tour.
Friday, October 10, 2025
https://www.bnl.gov/pittsburgh-diffraction-conference/nsls2tour.php

Banquet Dinner
Danfords Hotel and Marina
25 E Broadway, Port Jefferson, NY 11777
Date: Friday, October 10, 2025, 7-9 p.m.

 

Awards Dinner
Charles B. Wang Center
100 Nicolls Road, Stony Brook, NY 11794
Date: Saturday, October 11, 2025, 7-9 p.m.

We bring together experts at the intersection of microscopy and mass spec, topics include soft landing, holography, cryoEM, AFM, native MS, top-down proteomics and various single molecule imaging and mass spectrometry techniques to characterize (biological) macromolecules.

Invited speakers:

 •   Aleksandar Antanasijevic, Ecole polytechnique federale de Lausanne, Switzerland
 •   Petr Chlanda, Heidelberg University, Germany
 •   Irina Gutsche, Institut de Biologie Structurale, Grenoble, France
 •   Ohad Medalia, University of Zurich, Switzerland
 •   Christopher Russo, MRC Laboratory of Molecular Biology, Cambridge, UK
 •   Veijo Salo, The European Molecular Biology Laboratory, Heidelberg, Germany
 •   Itziar Serna Mart?n, Thermo Fisher Scientific, Netherlands
 •   Sebastian Tacke, Max Planck Institute of Molecular Physiology, Dortmund, Germany
 •   Ilaria Testa, KTH Royal Institute of Technology, Stockholm, Sweden
 •   Sonja Welsch, Max Plack Institute of Biophysics, Frankfurt, Germany
 •   Xiaodong Zou, Stockholm University, Sweden

cryoNET speakers:

 •   Mira Dombi, University of Copenhagen, Denmark
 •   Max Renner, Umea University, Sweden
 •   Klara Theresa Scholtissek, Aarhus University, Denmark
 •   Sebastian Valenzuela, University of Gothenburg, Sweden