Topics:

• The development of various 3D electron diffraction/MicroED techniques â€" a historical perspective
• Introduction to transmission electron microscopy and electron diffraction
• 3D electron diffraction/MicroED (SAED, PED, EDT) and space group determinationÂ
• Sample preparation for both materials and life sciencesÂ
• 3D ED/MicroED Data collection  Â
• Radiation damage  Â
• 3D ED Data Processing and data merging including practical demo labs
• Methods for phasing diffraction data â€" small molecules and macromolecules
• Practical demo labs for structure solution and refinement with 3D ED/MicroED data â€" two groups for small molecules and macromolecules, respectively
• Dynamical refinement
• New developments in 3D electron crystallography

This one month course, coordinated by the Université Grenoble Alpes, is designed to provide training for students, postdoctoral and senior scientists from European and non-European universities and laboratories, in the field of Neutron and Synchrotron Radiation for condensed matter studies (Biology, Chemistry, Physics, Materials Science, Geosciences, Industrial applications). It includes lectures, practicals and tutorials, visits of Large Facilities and a poster session (each participant puts up a poster about her/his thesis or research topic for a day).

• PART I: BASIC METHODS AND INSTRUMENTS :
  (This part is common for all the participants - 1.5 weeks)
• PART II is divided into two parallel specialized sessions (3.5 weeks) :
  • Session A: PHYSICS AND CHEMISTRY OF CONDENSED MATTER
  • Session B: BIOMOLECULAR STRUCTURE AND DYNAMICS

The language of the course is English.

This workshop is aimed at PhD students, post-doctoral fellows and any researchers or engineers involved in the field of bio-crystallography.Â

The workshop will contain lecture classes and hands-on experimental sessions, which will include time for the collection and processing of X-ray diffraction data collected on the Proxima-1 and Proxima-2A beamlines at SOLEIL.

Participants are invited to attend a MOOC session, which is accessible here, prior to attending the workshop.

Registration is limited to 12 participants. Registration deadline: 31st January 2020.Â

Connecting B Cell Biology with Antibody Structure, Function and Applications

Linking Structure, Mechanism and Physiology of Ion Channels, GPCRs and Transporters

Linking Structure, Mechanism and Physiology of Ion Channels, GPCRs and Transporters

Steering Methods Toward Overcoming the Most Difficult Challenges in Structural BiologyÂ

The program will include the following sessions:

• QSAR without Borders
• Artificial Intelligence in Drug Design
• Molecular Dynamics and Kinetics
• Chemical Space Annotation and Expansion
• Modelling Drug Safety
• Challenges in GPCR Drug Design
• Modelling Drug Transport Mechanisms
• Predicting Off-Target Pharmacology
• Network Medicine
• New Modes of Target Interaction
• New Trends in Quantum Mechanics
• Future Challenges Ahead

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

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• Session 1 : Induced-proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers...
• Session 2 : Advances in Cryo-EM : Micro-ED, Sample Optimization and Grid Preparation
• Session 3 : Covalent Modifications for Drug Discovery
• Session 4 : Integrative Structural Biology & Biophysics - Including Computational Methods and Hybrid Methods
• Session 5 : Advances in Biophysical Techniques : Single-Molecule Techniques, Label-free Technologies, Surface-Immobilized Techniques beyond SPR...
• Session 6 : Hot Topics

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Chromatin Modifications, RNA and MetabolismÂ

Micro to Macro Chromatin Structure in Epigenetics and DiseaseÂ

This edition is particularly special as it celebrates 60 years since the founding of the British Biophysical Society. We have an excellent programme of speakers representing biophysics from the picosecond to the evolutionary time scales and from the nano to the macro length scales. Over 25% of speakers will be chosen from submitted abstracts and flash talks will be selected from poster presenters.

Confirmed speakers:
Richard Henderson (LMB)
Tony Watts (University of Oxford)
Banafshe Larijani (University of Bath)
Perdita Barran (University of Manchester)
Mike Fried (University of Kentucky)
Allen Orville (University of Oxford, Diamond Light Source)
Amanda Wright (University of Nottingham)
Tim Knowles (University of Birmingham)
Tom Clarke (University of East Anglia)
David Brockwell (University of Leeds)
Ben Luisi (University of Cambridge)
Peter Crowley (National University of Ireland, Galway)
Corinne Smith (University of Warwick)