The International School of Crystallography has been active since 1974, and over the years has brought together a remarkable number of scientists from many different countries. The purpose of the 55th course is to provide the students with

• An overview of the current structural and biophysical techniques used in the field;
• The use of informatics tools in drug discovery;
• The evolving role of chemistry in drug design and biology understanding; and
• An introductions to biologics and their applications.

Speakers committed to participate to the school include Tom Blundell (Cambridge UK), Charles Lesburg (MSD, Boston, USA), James Frasier (UCSF, S. Francisco, CA, USA), Lucia Banci (Florence University, Italy), Ben Davis (Vernalis, Cambdrige, UK), Sandra Jacob (Novartis, CH), Georgia McGaughey (Vertex, USA), and Eddy Arnold (Rutgers, NJ, USA).

Fifth intensive HOW-TO course in BioSAX

Students will have two days of lectures and hands-on software tutorials on the
basics of BioSAXS data collection and processing from expert practitioners
in the field. This will be followed by data collection on the BioCAT
beamline (Sector 18 at the APS) and data analysis help. Students are
encouraged to bring 1-2 research samples for the data collection.

Also, for the first time ever, BioCAT is offering this course for remote
participants. Remote participants will get a live-stream of the lectures,
and all of the tutorial materials. They will not be able to collect data.

Registration for on-site participants is first come, first served, and limited to the
first 15 registrants due to time constraints on how many users can collect
data during the course.

Â

We are pleased to announce that the next CCP4 Study Weekend in its 2020
edition will be devoted to the single most synergic task in structural
biology: model building. Aside from covering the latest advances in both
automated and manual procedures, the meeting will offer sessions on related
topics such as refinement, validation and representation, with a focus on
helping you produce the best possible model from your experimental data.
All sessions will have an integrative character, presenting methods and
approaches that may be indistinctly used with X-ray crystallography, and
electron cryo-microscopy or diffraction.

This meeting will have a couple of innovations too - more announcements
will follow in due course. The most important ones will be posted here (as
always), but for more fluid news, speaker profiles and direct communication
with the organisers, please use hashtag #CCP4SW on Twitter or give us a
follow (vide infra).

As in recent editions, the event will be held at the East Midlands
Conference Centre in Nottingham, from the 7th to the 9th of January 2020.
We are very much looking forward to welcoming you in Nottingham. And yes,
there will be a Cèilidh (https://en.wikipedia.org/wiki/Cèilidh).

Registration and programme details: https://tinyurl.com/ccp4sw2020

Major topics covered includeÂ

• Single particle cryoEM (theory, hands-on specimen preparation, insight into data collection and hands-on image processing practicals).
  
• Cellular tomography (Both theory and sub tomogram averaging practicals) and
  
• Talks on MicroED - 3D electron Crystallography and its application.Â

Speakers include 2017 Nobel Laureate in Chemistry Professor Joachim Frank (Columbia University).

The course will cover X-rays, neutrons and electrons diffraction by crystals of biological
macromolecules. Various techniques will be investigated:
• Macromolecular crystal growth
• In situ (in plate) X-ray diffraction
• Serial X-ray crystallography
• Time-resolved X-ray crystallography
• Neutron diffraction
• Electron diffraction of nano-crystals
with the aim of solving de novo structures, searching ligands, elucidating reaction
mechanisms...

This 4-day course will combine theoretical lectures and practicals on the EPN instruments.
It is dedicated to researchers (advanced PhD, PostDoc, Scientist) interested in
macromolecular structural studies at atomic resolution using crystallographic approaches.
The course will take place from November 19 to November 22, 2019 at the EPN campus,
Grenoble, France. To apply, please, send a short CV (1 page max.) and a motivation letter
to [email protected] before September 30, 2019.

The registration is free and includes accommodation and meals on the EPN campus.
Selected applicants will be notified by e-mail by October 15, 2019. Participants will have to
pay for their travel expenses. More details about the workshop can be found on the
dedicated web site: http:// workshops.ibs.fr/adtb-2019

ADTB is funded by IBS, EMBL, ESRF, CBS, FRISBI, CRISTECH, AFC, UGA, Grenoble
INP, CNRS, CEA

Â

The Workshop will address essential questions and challenges of radiation damage to biological samples during their examination with ionizing radiation. The workshop will cover various X-ray and electron scattering techniques, from crystallography to imaging, and offers ample opportunities for information exchange and discussion among researchers from around the globe.
Please go to https://indico.psi.ch/e/rd11 for first information on the event.
Registration will open in October 2019. Further details will be available shortly.

** If you have suggestions for speakers please send them to [email protected] or [email protected] or submit an abstract on the website. **

A two-day event at Michigan State University to celebrate the grand opening of the new cryo-EM facility

TOPICS include:

 *  Integrative Structural Biology
 *  Biophysical Techniques
 *  X-ray Crystallography
 *  Bio-NMR
 *  Cryo EM
 *  Drug Discovery
 *  Methods Developments
 *  Synchrotrons news
 *  Scientific Integrity

This Course covers the major
structural and biophysical techniques employed for characterization of
proteins and nucleic acids under close to native conditions. It includes
lectures on: small angle X­-ray and neutron scattering, NMR, mass
spectrometry, analytical ultracentrifugation, bioinformatic tools,
cryo­EM and interdisciplinary approaches. The registration fee of 170
euro will be requested from the academic participants covering the event
materials, lodging and meals. A limited number of travel grants and
child care grants are available.

The course will focus on structural biology using Transmission
Electron Microscopy and aims to teach the participants the basic principles
and practical aspects of specimen preparation, data collection, Image
processing and 3D reconstruction in Single Particle Cryo Electron
Microscopy(SPCryoEM) and Cellular Tomography. This is a hands-on course,
in which theory and practicals are tightly intertwined. There will be
practical session to teach sample preparation for Single particle â€"ve stain
and cryoEM and data collection. Subset of participants will be encouraged
to bring their samples. The topics covered will suit both the new entrants
to the field as well as those who wants to acquire an in-depth
understanding of the fundamental principles and practical aspects.
Applications are invited from PhD students, Post Docs and Researchers
(Faculties/PI’s and protein crystallographers) who wish to acquire
knowledge in SPCryoEM and Cellular Tomography. Applicants from all over
the world are encouraged to apply.

This Course covers the major structural and biophysical techniques employed for characterization of proteins and nucleic acids under close to native conditions. It includes lectures on: small angle X­-ray and neutron scattering, NMR, mass spectrometry, analytical ultracentrifugation, bioinformatic tools, cryo­EM and interdisciplinary approaches.

The purpose of the conference is to provide a forum for students and
postdocs to meet established researchers as well as some rising stars, and
to see and discuss presentations on the latest methods and results.

Keynote speakers are Ilme Schlichting, David Stuart, Erica Ollmann Saphire,Robert Stroud, Suzanne Scarlata, David Eisenberg, Wayne Hendrickson, Yvonne Jones, Eva Nogales, and Tom Blundell

There are a number of fellowships covering hotel and registration available
for students and postdocs. Successful applicants will be notified on a
rolling basis about a month after they register for the conference.

After the main conference there will be an optional Phenix workshop with
lectures and hands-on sessions on using Phenix for crystallography and
cryo-EM.

Â

The goal of this workshop is to teach new cryo-EM users how to prepare samples for imaging on cryo electron microscopes, primarily through hands-on tutorials, discussions and introductory talks.

Topics

Introductory Lectures: • An introduction to the basics of cryo-EM and cryo-ET • The complete guide to sample vitrification  Hands-on sessions: • Sample preparation for single particle cryo-EM • Sample screening at eBIC and an introduction to data collection on Titan Krios, Glacios and Talos Arctica Â

Major Topics:

• Atomic resolution: SPA â€" proteins to macromolecular complexes
• Molecular resolution: macromolecular complexes to organelles
• Cellular resolution â€" Organelles to Cells
• Beyond cells â€" tissues and organs
• Biophysical techniques and instrumentation to study biological structures
• Multiscale modeling and interpretation

Abstract deadline is July 12, 2019