The workshop is focused on areas important for all researchers and
specialists working in the field of structural biology or utilizing one or
more methods of structure analysis of biological macromolecules.

The skills and tools for combining experimental approaches and
computational tools in structural biology are in the center of this event.
Theoretical lectures will be complemented by user cases and practical
tutorials on laboratory equipment and in computational analysis.

The meeting will be held at the Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Workshops will take place on Sunday the 3rd of November, followed by a welcome reception. Scientific sessions and exhibition will be held on Monday the 4th and Tuesday the 5th of November, with a conference dinner in central Cambridge on the 4th.

Scientific talks will cluster around the following major themes:

• structure and biophysics based drug design stories
• cryoEM in a pharmaceutical setting
• popular biophysics techniques, eg. HDX-MS
• popular drug discovery trends, eg. degraders

Workshops will include three consecutive sessions about biophysics, crystallography and cryoEM.

Important dates:

• Early Bird registration closes 22nd July 2019
• Registration closes: 28th October 2019

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The course aims to cover the theoretical and practical aspects of protein
crystallography from protein expression and purification, through crystal
growth to data collection on in-house and synchrotron sources, phasing
methods, automated model building and phase extension, refinement, and
validation. Hands-on sessions in data processing (XIA2, DIALS), molecular
replacement, MAD/SAD phasing, refinement and electron density map
interpretation (in COOT) will be included.

The School is intended for postgraduates or postdocs new to
crystallography. The week is very intensive, and gives a concentrated
overview of the methods which many find useful.

As in the past, priority is given to UK applicants because of the funding
arrangements, but is open to a limited number of overseas applicants.

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The event focuses on XFEL and Cryo-EM science.

The Francis Crick Institute will host a two-day symposium exploring the impact of electron microscopy on biomedical research across scales, with a focus on correlative imaging. We have an exciting line-up of talks from imaging scientists at the cutting edge of correlative microscopy development and application, from macromolecules to whole organisms, and from biomedical scientists who apply these techniques to reveal new insight into health and disease. The symposium follows the 2017 Crick EM Opening Symposium, which united researchers and technology developers from the high-resolution single particle cryo-EM through to the large-volume brain imaging communities, with more than 350 attendees and a large hands-on exhibition from more than 20 commercial collaborators.

This meeting celebrates phages, viruses, and has a strong cryo-EM focus on assemblies related to phage and virus biology. This is a trainee-focused meeting and we encourage abstract submission from students and postdocs to give oral or poster presentations.

The 7th annual meeting of CCP-BioSim is organised jointly with the Molecular Graphics and Modelling Society and will have the theme of Modelling and Simulation for Synthetic Biology. The conference will showcase important advances in biomolecular modelling and simulation tools, technologies, interplay with experiment, and applications to biomolecular design and synthetic biology.

Topics of interest, but not limited to, include the following:

• Structure representations
• Structure prediction and refinement
• Structure comparision and alignment
• Molecular interaction, docking and simulation
• Coarse grained modeling
• Mining structural data
• Structural genomics
• Applications of high performance computing to structural problems
• Applications of graph theory and optimization to structural problems
• Structure-based drug design
• Biomolecular graphics

 Biomedicum, Karolinska Institutet

The 2nd CryoNet Annual Symposium will highlight the latest discoveries in protein-nucleic acid complexes along with a view to the future of cryo-EM. Alongside presentations on important biological results will be exciting methodological advances emphasizing that cryo-EM is still in a major growth phase.

Students and postdocs are encouraged to apply to give talks and poster presentations

CryoNet is funded by the Knut and Alice Wallenberg Foundation and the Novo Nordisk Foundation

The Workshop, which will consist of lectures and hands-on sessions, is aimed to PhD and undergraduate students as well as research staff interested in protein X-ray diffraction methods. The number of places is limited (maximum 40 people).
Deadline for registration: June 7, 2019

Bursary
For PhD candidates from outside Poland there are stipends available from the PROM programme to cover fee, travel and stay costs.
The application form and further information at: http://www.ik-pan.krakow.pl/Artykul.27+M516df2adb92.0.html
Deadline for stipend application: May 17, 2019

The annual CHESS Users' Meeting will be held June 4-5, 2019 at Cornell, Ithaca,
NY. CHESS has just completed a major upgrade to its storage ring and beamlines;
the meeting will be a great place to find out about the new opportunities for
science created by CHESS-U, and see the new facilities.

There will be two workshops at the meeting; of particular interest to this
audience is one on Biomolecules Under Pressure. Speakers will introduce
high-pressure bioscience as it relates to molecular biophysics, the evolution of
life, food science and the instrumentation required to perform high-pressure
biological experiments, primarily using crystallography and SAXS. The workshop
will include a short overview of data acquisition at the CHESS BioSAXS station.

To be held at Birkbeck College, University of London

The aim of the course is to teach the basic principles and practical aspects of image processing to structural and molecular biologists wishing to determine macromolecular structures by cryo EM. The course will concentrate on processing of high-resolution image data, for both single particle images and tomograms, and will be aimed at advanced PhD students and postdocs using cryo EM for structural analysis.

The VU Amsterdam and the Dutch Crystallographic Society (NVK) will host a 1-day Structural Biology Symposium. During this one day symposium new results and key questions and issues in structural biology and imaging will be addressed, in particular:

• High-resolution 3D structures of macromolecules and macromolecular complexes using X-ray diffraction, Cryo-EM and Electron microdiffraction
• Protein-Protein and Protein-Nucleic acid interactions
• Drug design
• Diffuse Scattering

The programme will address the limiting step in structural studies - the production of
pure and homogenous proteins. Talks and discussions at this event will explore strategies
to optimize membrane and soluble proteins for crystallization, cryo-EM and NMR studies.
Discussions will include construct optimization, novel thermostability assays,
crystallization tools and `tricks of the trade' to enable structure determination.

This event is particlarly directed toward early-stage graduate students in structural biology.
However, anyone interested in generating soluble proteins for a variety of applications,
such as enzymatic assays and antibody production, would be welcome to attend.
Manufacturers of instruments and techniques to assay purity and homogeneity
will be available for hands-on demonstrations.

The list of invited speakers are experienced in the structure determination of
membrane proteins, cytosolic/secreted proteins, and macromolecular signaling complexes:

Edmund Kunji, Cambridge
Daniel Panne, Leicester
Maria Sasi Conte, King?s College
Naomi Chayen, Imperal College
Laura Itzhaki, Cambridge
Chris Tate, Cambridge

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The JCNS Workshop will bring together experts in neutron scattering methods with users from soft matter and biology to review techniques and provide the opportunity for the community to discuss current limitations, new capabilities, and future developments.

This immersive course is an outstanding place to learn both the theoretical and practical aspects of Macromolecular Crystallography because of the extensive lectures from world-renowned teachers, which are combined with hands-on experiments. This 2019 course will be lead by Jim Pflugrath (Rigaku, ret.), Tassos Perrakis (NKI), Paul Adams (LBL), Janet Newman (CSIRO) and an All-Star cast of lecturers. Attendees can expect to participate in a course that is unparalleled in the world, with experts each devoting several days to teaching the fundamentals, theory and practical considerations of crystallographic structure solution.

Topics to be covered include:

• Basic diffraction theory
• Crystallization (proteins, nucleic acids, complexes and membrane proteins)
• Synchrotron X-ray sources and optics
• Data collection and processing
• Structure solution by experimental phasing methods (SAD, MAD, MIR, and others) and molecular replacement
• Electron density maps improvement
• Model building and refinement
• Structure validation
• Coordinate deposition
• Structure presentation

The course is limited to 16 participants due to the very hands-on nature of the experiments and the intimate seminar room and laboratory settings. Please check the above web link for more details. In particular, please note the information about fellowships, scholarships, and stipends that are available. It is often possible for applicants to receive some level of support to help offset the course fee.

This course is supported with funds provided by the National Institute of General Medical Sciences for which we are extremely grateful. Also there are stipends available from the Leona M. and Harry B. Helmsley Charitable Trust and the Howard Hughes Medical Institute to help offset the cost of tuition.Â