Topics:

• The development of various 3D electron diffraction/MicroED techniques â€" a historical perspective
• Introduction to transmission electron microscopy and electron diffraction
• 3D electron diffraction/MicroED (SAED, PED, EDT) and space group determinationÂ
• Sample preparation for both materials and life sciencesÂ
• 3D ED/MicroED Data collection  Â
• Radiation damage  Â
• 3D ED Data Processing and data merging including practical demo labs
• Methods for phasing diffraction data â€" small molecules and macromolecules
• Practical demo labs for structure solution and refinement with 3D ED/MicroED data â€" two groups for small molecules and macromolecules, respectively
• Dynamical refinement
• New developments in 3D electron crystallography

As in previous years, we will offer a combination of lectures covering the theoretical aspects of powder diffraction and Rietveld refinement, classroom-based "by-hand" problem sessions/tutorials and extensive hands-on practical sessions using a variety of modern software packages.

Topics to be covered will include:

• Data collection strategies for X-ray and neutron diffraction
• Constant wavelength and time of flight diffraction
• Modelling peak shapes
• Indexing powder patterns
• Rietveld, Le Bail and Pawley fitting methods
• X-ray and neutron combined Rietveld refinement
• Extended solids and molecular systems
• Restrained refinements
• Rigid body refinements

• An overview of the current structural and biophysical techniques used in the field;
• The use of informatics tools in drug discovery;
• The evolving role of chemistry in drug design and biology understanding; and
• An introductions to biologics and their applications.

AICS2019 offers an intensive course in Crystallographic Information, covering the extraction, dissemination and use of scientific knowledge from the structure determination experiment to database-driven discovery. This school will emphasise to students the need to collect the most complete and meaningful raw data, extract the most reliable information they can, critically review the structural model they have derived, and disseminate that information in a complete and verifiable manner through the twin channels of scientific publication and curated database deposition.

The targeted audience for this school is a non-specialist one: PhD students, young or experienced scientists working in the field of crystallography, chemistry, material science or solid state physics who want to have a basic understanding of aperiodic crystals are encouraged to apply.

The number of participants is limited to 40. Tutorials in small groups will be organised in order to practice the content learned in the lecture courses.Â

Registration deadline: 15th June 2019

Registration costs vary according to career stage of the applicants. The registration fees are all inclusive, and hence cover the cost of accommodation and meals for the entirety of the school. Please visit the school website for more information and the specific registration costs.