PURPOSE OF THE COURSE

Over the last 50 years, crystallography has developed from a method capable of determining the structures of isolated, soluble proteins to one able to provide detailed information on mechanisms of action of integral membrane proteins, whole viruses and the complex nano-machines that are central to cellular function. To discover how biology works researchers are now combining the power of crystallography with multiple other methods, spanning from the atomic to cellular scale, and including revolutionary developments in electron cryo-microscopy and tomography. This Course will celebrate its milestone as the 50th in the crystallography series started by Dorothy Hodgkin by focusing on integration:

1. of different techniques,
2. of molecular and cellular approaches and
3. of the crystallographic community, including diversity.

The aim is to provide young researchers with a review of the fundamental approaches and latest developments in the application of crystallography and hybrid methods to the structure and function of biological macromolecules and complexes. Lectures will exemplify use of integrated approaches to analyse molecular mechanism in human and pathogen biology. There will be hands-on workshops to provide practical experience and in-depth

discussion of topics ranging from sample preparation to data analysis software. To commemorate the achievements of the Erice crystallography school over the past 50 years, the course will feature several sessions that reflect on the past and look to the future to highlight the factors that create an inclusive discipline.

APPLICATIONS

Interested candidates should register by 30th November 2016 using the form available in the school website (crystalerice.org).
Applicants may be able to apply for partial financial support. Please visit cristalerice to view the full eligibility criteria.

CURRENT LIST OF SPEAKERS AND TOPICS

• Nenad Ban (ETH Zurich):Â Protein synthesis by large cellular assemblies
• David Barford (LMB Cambridge): The anaphase-promoting complex
• Pamela Bjorkman (Caltec):Â Â Immune recognition of viral pathogens
• Tom Blundell (Cambridge University):Â Â TBD and "Celebrating the 50th International School of Crystallography"
• Bridget Carragher (NYSBC):Â Intro to Cryo-EM
• Wah Chiu (Baylor College of Medicine):Â Electron cryo-microscopy of biological nanomachines
• Elena Conti (MPI for Biochemistry):Â RNA metabolism
• Piet Gros (Utrecht University): The complement system
• Sun Hur (Harvard University):Â Signal transduction by immune receptors
• Yvonne Jones (University of Oxford):Â Cell surface signaling assemblies
• Werner Kühlbrandt (MPI for Biophysics): Membrane proteins: Structure and mechanisms
• John Kuriyan, (UC Berkeley):Â Cellular signal transduction
• Debora Marks(Harvard University):Â TBD
• Jenny Martin (Griffith University):Â Antimicrobial drug design
• Naoko Mizuno (MPI for Biochemistry):Â TBD
• Poul Nissen (Aarhus University):Â Membrane transporters in the brain
• Lori Passmore (LMB Cambridge):Â TBD
• Michael Rossmann (Purdue University):Â The structure of the Zika virus
• Michael Rout (The Rockefeller University:Â The nuclear pore complex
• Giovanna Scapin (Merck & Co):Â Â Structural Biology in Drug Discovery
• Irmi Sinning (Heidelberg University):Â Protein targeting and membrane protein biogenesis
• Titia Sixma (NKI Amsterdam):Â Molecular mechanisms in carcinogenesis
• David Stuart (University of Oxford):Â Virus structure and vaccine design
• Sriram Subramaniam (NCI Bethesda):Â Â Â High resolution electron microscopy
• Alessandro Vannini (ICR London):Â Â TBD
• Antoine van Oijnen (University of Wollongong):Â Single molecule biophysics
• Wei Yang (NIDDK Bethesda):Â Â Â Â DNA repair, replication and recombination
• Xiaodong Zhang (Imperial College London):Â Â Â DNA processing and damage response

WORKSHOPS

• Riccardo Pellarin (Pasteur Institute): Integrative Modeling Platform
• Cornelius Gati (MRC): RELION
• Randy Read (MRC): Validation/errors
• Paul Emsley (MRC) :COOT
• Debbie Marks & Chris Sanders (Harvard): EV fold
• Airlie McCoy (MRC): Solution and refinement of large complexes/low resolution systems
• Ardan Patwardhan (EBI/PDBe): EMDB/EMPIAR:Â linking structural information from molecules to cells

Satellite Meeting of the IUCr Congress

The 2017 EMU (European Mineralogical Union) School

The school will cover different multidisciplinary aspects related to the study of natural fibres and is thus aimed at students with a background in Biology, Chemistry, Geology, Material Science, Medicine, Physics who strive for working in the field of mineral fibre and asbestos and want to acquire both a strong background in this specific area of environmental protection and a multidisciplinary open vision of the asbestos related problems.

The following topics will be covered:

• Crystal structure and crystallography, occurrence of mineral fibres, and natural occurring asbestos
• experimental methods for the investigation of mineral fibres: optical microscopy, X-ray diffraction, electron microscopy, vibrational spectroscopy, iron spectroscopy and synchrotron radiation based techniques
• Surface and bio-chemical properties of mineral fibres
• Illustration of asbestos related diseases and bio-chemical mechanism inducing toxicity effects in the human body
• In vitro and in vivo tests to assess cyto/genotoxicity and carcinogenicity of mineral fibre
• Dissolution and biodurability of mineral fibres
• Epidemiological studies of asbestos related diseases
• Genetic factors, mutations and toxicity of mineral fibres

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The School is intended primarily for young researchers in the chemical, molecular and solid state sciences. Applicants from all regions of the world will be considered. The goal is that the participants gain hands-on experience plus a theoretical background in the art and science of routine crystal and molecular structure determination of small molecules by single-crystal X-ray crystallography, as well as in the interpretation and presentation of results. The School will consist of lectures, computer exercises and practical work. The School is ideal for anyone for whom a knowledge of crystal structure analysis would be particularly helpful in their current reseach.

Themes and Scientific Sessions

Scientific Themes

• Energy
• Environment
• Health

Special Scientific Sessions or Initiatives

• Biomolecular: Complex Nucleoproteins Cellular Machines
• Energy Storage and Production
• Renewable Energy
• Soft-Matter Self-Assembly: Pathways and Kinetics
• Polymers, Colloids
• Material Science
• Magnetic Materials
• Catalysis
• Grazing Incidence Techniques
• Combined Techniques (includes in situ)
• Dynamics, Kinetics, and Time-Resolved
• Educating the Community (for small-angle scattering teachers)
• Advances in Modeling and Data Analysis (especially two-dimensional)

Recent advances in x-ray absorption spectroscopy covering experiment, theory and instrumentation.

The proceedings are streamed live at https://livestream.com/fccollege/.

The 13th International Conference on Quasicrystals (ICQ13) will be held on 18-23 September 2016 in Kathmandu, Nepal. This is one of the series following the 1st workshop in Les Houches, France, the 2nd in Beijing, China, the 3rd Meeting in Vista-Hermosa, Mexico, the 4th Conference in St. Louis, USA, the 5th in Avignon, France, the 6th in Tokyo, Japan, the 7th in Stuttgart, Germany, the 8th in Bangalore, India, the 9th in Ames, USA, the 10th in Zürich, Switzerland, the 11th in Sapporo, Japan, the 12th in Cracow, Poland.

The ICQ13 offers an opportunity for researchers working on quasicrystals and related topics to exchange ideas and encourage collaborations with other research groups, hence promoting material science and engineering. It brings all the best scientists in the world to talk about the recent developments in the field. Abstracts are invited in all areas of research including (but not limited to) the following topics:

• Formation, growth and phase stability
• Structure and modeling
• Mathematics of quasiperiodic and aperiodic structures
• Physical properties: transport, magnetic, dynamical, mechanical etc.
• Surfaces and overlayers
• Applications and New Frontiers
• Metamaterials: polymer, macro molecules, photonic/phononic crystals, oxide etc.
• Related topics: incommensurate/modulated structures, metallic glass, complex metallic alloys, clathrate compound, clusters etc.

Plenary talks:

• Dave Mao (HPSTAR, China)
• Chi-Chang Kao (SLAC National Accelerator Laboratory, USA)

Sessions:

• High-pressure chemistry and synthesis
• Mineral physics and planetary materials
• Computational approaches
• High-pressure materials and physics
• Polymorphism and crystal chemistry
• Synchrotron techniques
• High-pressure spectroscopy
• Amorphous materials
• New Frontiers in Extreme Conditions Crystallography

Social program:

• Tour of PAL and PAL-XFEL facilities
• Day tour of the historic Gyeongju city

The conference focuses on research which advances experimental techniques across the very widest range of applications in mechanics, including stress, strain and vibration
analysis

Plenary lectures

G. R. Desiraju: From molecule to crystal

Ron Lifshitz: What is a crystal? - New answers to an old question

Keynote lectures

Alessia Bacchi: Crystal engineering and structural chemistry: function through design_1

Robert Mokaya: Inorganic Materials and Industry Minerals

Alejsandro Buschiatto:

Colin Groom: Crystallography data bases

Gilberto Artioli: Inorganic Materials and Mining Industry

Ashwini Nangia: Crystal engineering and structural chemistry: function through design_2

Robert F. Stewart school on electron density and related properties

High resolution X-ray diffraction and polarized neutron diffraction are the most relevant methods for respectively modeling charge density and magnetic moment (spin) distributions. Combining both experimental methods in a joint refinement leads to a precise spin resolved electron distributions in magnetic materials.

The aim of this School is to teach all participants the basic knowledge about paired and unpaired electron density distributions using neutron and X-ray diffraction methods and to practice existing refinement software.

This school is dedicated to electron density and its analysis with the emphasis on the combination of complementary experimental methods to enrich the electron density models leading to more complete description of the electronic behavior of crystalline solids.

The school will end with a round table about application of topological analysis and electrostatic properties of a charge distribution in chemistry, biochemistry and physics. Also we will discuss the role of the spin density in material science and how to combine experimental and theoretical methods for a better electron density modeling.

Target Audience: The audience will be typically early career scientists e.g. assistant professors, post-doctoral research fellows, and graduate students of crystallography, medicinal chemistry, solid state and materials science, biochemistry, theoretical, quantum and computational chemistry.

The number of participants is limited to 50.

The bursaries application can be made for ECA and AFC

Topics of the School

• Solution properties
• Nucleation: classical and non-classical approaches
• Crystal growth kinetics and mechanisms
• Crystallization routes
• Crystallization techniques
• Crystal morphology
• Mineral textures
• Polymorphism
• Hydrates and solvates
• Crystallization screening
• Industrial (mass) crystallization
• Chirality
• Biomineralization
• Co-crystals
• Diamonds growth

• Intended for advanced PhD students, postdocs and young scientists
• Theoretical and in-depth tutorial training on state-of-the-art methods in macromolecular crystallography

• 25 available places for selected students
• Grants available with all expenses covered
• APPLICATIONS until January 20th, 2016 at http://www.ifsc.usp.br/mx2016

Main Topics

• Diffraction data processing
• Phasing and structure determination
• Model refinement and validation

Speakers and Tutors

• Alejandro Buschiazzo Montevideo, Uruguay
  
• Kay Diederichs Konstanz, Germany
  
• Paul Emsley Cambridge, UK
  
• Richard Garratt São Carlos, Brasil
  
• Ronan Keegan Oxford, UK
  
• Eugene Krissinel Oxford, UK
  
• Joana Pereira Hamburg, Germany
  
• Andrey Lebedev Oxford, UK
  
• Andrew Leslie Cambridge, UK
  
• Garib Murshudov Cambridge, UK
  
• David Waterman Oxford, UK
  
• Pavol Skubak Leiden, The Netherlands
  
• Randy Read Cambridge, UK
  
• Andrea Thorn Cambridge, UK
  
• Isabel Uson Barcelona, Spain