8:00 - 9:30 a.m. (PST).

Speakers:
Prof. Brian Kobilka (2012 Nobel Prize in Chemistry)
Stanford University Medical School
Talk title: "Mechanistic insights from cryoEM enabled structures of G protein coupled receptors"

Prof. Eva Olsson
Chalmers University of Technology
Talk title: "In situ TEM with piezo-driven manipulation, probing and perturbation"
Please register soon at:
https://stanford.zoom.us/webinar/register/WN_eMxleNraRhmREedt141IWw 

Within this Conference there is the Michael G. Rossmann Memorial Symposium which focuses on the application of hybrid methods in electron microscopy of viruses, enzymes and other macromolecules, areas in which Michael was a pioneer.

The symposium will feature invited talks from Prof. Hao Wu (Harvard Medical School), Prof. Rui Zhao (University of Colorado School of Medicine), and Prof. Chuan (River) Xiao (University of Texas El Paso).
 

We invite abstracts from speakers in academics and industry at all career levels who develop and apply cutting-edge structural biology approaches to the study of viruses, viral proteins, enzymes, membrane proteins, and other systems. Ten abstracts will be selected for 15-minute oral presentations whereas the remaining abstracts will have the opportunity to be selected for poster presentations. Please note that the deadline for abstract submission is February 18, 2021. You will have the opportunity to select your preference for either in-person or virtual presentation.

On May 4-5, 2021, a special symposium will be hosted by the American Society for Biochemistry and Molecular Biology.

PDB50 will mark an important milestone in the history of structural biology. In 1971, the structural biology community established the single worldwide archive for macromolecular structure data â€" the Protein Data Bank (PDB). From its inception, the PDB has embraced a culture of open access, leading to its widespread use by the research community. PDB data are used by hundreds of data resources and millions of users exploring fundamental biology, energy and biomedicine.

Structural biology and structural bioinformatics have had an enormous impact on our understanding of the mechanism and function of biological macromolecules. The PDB acts as a custodian for all these data, representing a repository of the vast majority of the achievements and milestones of the structural biology community. The archive is managed by the Worldwide Protein Data Bank consortium (wwPDB) of partner sites in Asia, Europe and America.

This celebration of the 50th anniversary of the founding of the Protein Data Bank as the first open access digital data resource in biology will include presentations from speakers from around the world who have made tremendous advances in structural biology and bioinformatics. Students and postdoctoral fellows are especially encouraged to attend and will be eligible for poster awards.

The online sessions will take place between 11 a.m. â€" 4:30 p.m. EST each day.

The event will be recorded and made available to registered participants after the meeting.

Important dates

Speakers will include:

• Edward Arnold, Rutgers, The State University of New Jersey
• Helen M. Berman, Rutgers, The State University of New Jersey and University of Southern California
• Thomas L. Blundell, University of Cambridge
• Alexandre M. J. J. Bonvin, Utrecht University
• Stephen K. Burley, Rutgers, The State University of New Jersey and University of California, San Diego
• Wah Chiu, Stanford University
• Johann Deisenhofer, University of Texas Southwestern Medical Center
• Juli Feigon, University of California, Los Angeles
• Angela Gronenborn, University of Pittsburgh
• Jennifer L. Martin, University of Wollongong
• Stephen L. Mayo, California Institute of Technology
• Zihe Rao, ShanghaiTech University and Tsinghua University
• Hao Wu, Boston Children's Hospital

Sponsorships

Sponsorship opportunities are available;Â contact the wwPDB Foundation for more information.

Organizers

• Celia Schiffer, University of Massachusetts Medical School
• Helen M. Berman, Rutgers, The State University of New Jersey;Â RCSB PDB
• Stephen K. Burley, Rutgers, The State University of New Jersey;Â RCSB PDB
• Jeffrey C. Hoch, University of Connecticut;Â BMRB
• Gerard J. Kleywegt, European Bioinformatics Institute;Â PDBe
• Genji Kurisu, Osaka University; PDBj
• John L. Markley, University of Wisconsinâ€"Madison; BMRB
• Sameer Velankar, European Bioinformatics Institute;Â PDBe
• Christine Zardecki, Rutgers, The State University of New Jersey;Â RCSB PDB

8:00 - 9:30 am Pacific Time (15:00 - 16:30 GMT)
Live from Stanford: join the Stanford EM-X community for our 2nd symposium
Richard Henderson
Group leader at MRC Laboratory, 2017 Nobel Prize winner in Chemistry
Frances M. Ross
Professor at Massachusetts Institute of Technology

Hosts: Prof. Bob Sinclair, Prof. Wah Chiu, Prof. Yi Cui, and Prof. Jen Dionne

The meeting has been organised by the UK EM Validation Network to present current thinking on cryo-EM map and map/model validation, and to consider future research directions that anticipate the growing needs in this area. The community effort to apply cryo-EM to structural proteins of SARS-CoV-2 has been a success story but has also highlighted the importance of structure validation.

Gerard Kleywegt (EMBL-EBI)

Garib Murshudov (MRC-LMB)

Elena Orlova (Birkbeck College)

Ardan Patwardhan (EMBL-EBI)

Alan Roseman (University of Manchester)

Peter B. Rosenthal (The Francis Crick Institute)

Maya Topf (Birkbeck College)

Martyn Winn (STFC)

The day will begin at 9am and will feature short talks by post-docs and graduate students, a poster session, a self-care power hour, a cryo-EM art contest judged by Prof. David Goodsell (Scripps Research,) a Keynote Panel about the future directions of cryo-EM, cryo-ET, and microED by Professor Rebecca Voorhees (Caltech), Dr. Danielle Grotjahn (Scripps Research), and Dr. Jessica Bruhn (Nanoimaging Services), and it will end with a virtual Happy Hour for all interested members of the community.

Confirmed speakers for the online version of the meeting include:

Chris Russo (MRC-LMB)
Joe Atherton (KCL)
Rouslan Efremov (VIB-VUB Center for Structural Biology)
Vicki Gold (University of Exeter)
Alex Noble (NYSBC)
Dimitry Tegunov (Max Planck Institute for Biophysical Chemistry)
Hongyi Xu (Stockholm University)

The meeting will hosted via Zoom and is free of charge but you will need to pre-register here:

https://urldefense.com/v3/__https://ukri.zoom.us/webinar/register/WN_7ZSLh1xWQcqjqtIE_I2Sjg__;!!Mih3wA!VS11IblTAvJKtc_iwtCmi_cPBxVv-FsDOKUVtND2saJ6WVC6pMO_K8b37Tf5datoVw$

Â

Crete 2020 - 1st International CryoEM Symposium/Workshop to be held at the University of Crete

 A series of morning lectures will cover fundamental aspects of cryoEM, SPA, tomography, image processing and molecular modelling. Afternoon hands-on sessions will provide practical experience on single particle analysis and sub-tomogram averaging with special emphasis on evaluation of results and model building into high and low resolution cryo-EM maps. Trainees will work together with instructors and have an in-depth hands-on opportunity to learn how to use the software packages SPHIRE (single particle), pyTOM (subtomogram averaging) and the modelling packages PHENIX, COOT, REFMAC (modelling and refinement into cryoEM maps) and several other tools.
 On Day 1 we will additionally hold a symposium. Our invited speakers will highlight recent developments in the field and showcase outstanding recent applications. Participants will have the opportunity to present their own work in a poster session and five poster presenters will be selected for a short talk.

Confirmed Speakers/Instructors
Werner Koehlbrandt/ MPI Biophysics, Frankfurt 'EMBO Keynote Lecture'
Susan Lea/ University of Oxford
Stefan Raunser/ MPI Mol. Physiology, Dortmund
Pavel Afonine/ UC Berkeley
Ariane Briegel/ Leiden University
Friedrich F?rster/ Utrecht University
Robert Nicholls/ MRC Cambridge
Joergen Plitzko/ MPI Biochemistry, Martinsried
Evangelia Chrysina/ NHRF Athens
Nektarios Tavernarakis/ IMBB-FORTH
Registration deadlines for the event are 30.04 (early bird) and 07.06 (final deadline). The registration fees include single room accommodation, breakfast, lunch, coffee breaks, local transport and some social events (travel has to be arranged separately).

13TH MARCH 2020: Note on the Coronavirus situation: A prediction about a possible influence of Corona on our event in ~7 months is of course not possible at the moment. The situation will be evaluated few months before the event and if necessary (hopefully not) the course will be postponed; slots will be reserved for successfully registered participants.

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Topics

• Sample preparation
• Structural and functional characterization
• Computational analysis of integral membrane proteins

• Theoretical and fundamental crystallography
• Molecular and mathematical modeling in Crystallography, structure-properties Relationships
• Defects, Microstructures and Textures
• Crystal Growth and crystallization
• Powder diffraction methods and techniques
• Electron scattering and diffraction (methods and techniques)
• Chemical Crystallography
• Spectroscopic methods in Crystallography (NMR, Raman, IR, etc.)
• Macromolecular Crystallography
• Nano and Micro sized Materials
• Micro- and mesoporous materials
• Biocompatible Materials
• Minerals and technogenic materials structures and properties
• Experimental Techniques and Equipment

Isabelle Grillo dedicated her scientific life to the art of mixing surfactants, nanoparticles, polymers, emulsion droplets, as seen through the eyes of small-angle scattering. She showed that it is the most elegant method to go to the heart of colloidal interactions, by probing the intricate balance of colloidal forces, the morphology and the evolution of complex fluids.

Through the words of her closest collaborators, this symposium will highlight her outstanding contribution spanning from fundamental approaches to very practical industrially relevant questions on everyday products.

Registration and abstract submission for posters is now open. The deadline for abstract submission is 23 February 2020.Â

The program will include the following sessions:

• QSAR without Borders
• Artificial Intelligence in Drug Design
• Molecular Dynamics and Kinetics
• Chemical Space Annotation and Expansion
• Modelling Drug Safety
• Challenges in GPCR Drug Design
• Modelling Drug Transport Mechanisms
• Predicting Off-Target Pharmacology
• Network Medicine
• New Modes of Target Interaction
• New Trends in Quantum Mechanics
• Future Challenges Ahead

The conference aims to provide a forum to highlight state of the art developments in computational cryoEM and related themes as well as showcasing outstanding recent biological applications.

Topics include instrument technology, sample preparation, image processing, single particle reconstruction, tomography and model building. The schedule will also include the Diamond Light Source biological cryo-imaging user meeting for eBIC & B24.