Re: re. Maximum Likelihood

[Eleanor Dodson <ccp4@ysbl.york.ac.uk>]

On Thursday 05 December 2002 12:55 pm, you wrote:
> Ton
> 	Did you ever hear of anyone trying to refine small molecule structures
> using maximum likelihood?  I one heard Randy Read suggest that it would
> be of little value, but wondered what evidence he had.
>
> Best wishes
> 		David


 No - but no reason why they shouldnt.. But in fact once the R factor is < 10, 
LS and ML behave in the same way..
And if you are not using restraints, the relative weighting isnt important..
E