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[SA_scat] =?windows-1252?q?Postdoctoral_Position_=96_Synchrotron_?==?windows-1252?q?scattering_and_analysis=2C_Australia?=

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  • Subject: [SA_scat] =?windows-1252?q?Postdoctoral_Position_=96_Synchrotron_?==?windows-1252?q?scattering_and_analysis=2C_Australia?=
  • From: <stephen.king@stfc.ac.uk>
  • Date: Tue, 23 Oct 2012 08:09:56 +0000
  • Accept-Language: en-GB, en-US
Postdoctoral Position – Synchrotron scattering and analysis
Monash University, Parkville Campus, Melbourne, Australia

The group is interested in structured materials for drug delivery applications, and conducts material science (materials design and characterization), in vitro evaluation (drug loading and release, cell interactions) and in vivo evaluation (bioavailability, disease models). We currently have three postdocs and eight PhD students in the group as well as two half technicians. The group is led by Associate Professor Ben Boyd and is part of the Drug Delivery, Disposition and Dynamics theme of Monash Institute of Pharmaceutical Sciences.

The project is funded through the Australian Research Council for three years, and will involve the investigation of colloidal structures formed during digestion of lipids from the viewpoint of oral drug delivery. Lipid-based formulations are increasingly of interest for delivery of poorly water soluble drugs. The structures that form depend very much on the lipid composition used in the drug formulation (usually in a capsule) and they all have differing capacities to solubilise drug and maintain drug in a dissolved form. There is evidence that the drug itself can also influence the structure formation. These issues are critical to the outcome. However, although there has been a reasonable amount of work around 'assembling' lipids to form structures that might be representative of compositions during digestion, it is only recently that we have started to look at using real-time synchrotron SAXS here in Melbourne at the Australian Synchrotron to obtain high resolution kinetic data and to try to study these systems in situ during the digestion process. We also plan to follow the fate of drug by detection of diffraction peaks and assignment to different polymorphic forms. The structures are dynamic and often complex mixtures of micelles, liposomes, emulsion droplets and ordered particles such as cubic phase particles and hexagonal phase particles, so the major modelling challenge will be to try to deconvolute some of these systems and obtain structural data on the multiple populations.

The right person will have extensive experience with using scattering modelling approaches and common software. This must be demonstrated, and could be SANS/NR but preferably SAXS. Preferably they will have synchrotron experience as although a PhD student will take most of the hands on experimental burden, the postdoc will definitely help with planning, contributing ideas to improve experimental configuration and take part in experiments. Some aligned expertise would be valuable, such as cryoTEM or other imaging techniques. The postdoc would have around 20% of time to pursue their own interests in this area as well as contribute to other projects in the group as appropriate.

The starting salary will be AUD $72756 per annum (equivalent to USD $71007, or Euro 56035). Some relocation assistance may also be available. The position is available as soon as the right candidate is found.

If interested in this position, please contact ben.boyd@monash.edu<mailto:ben.boyd@monash.edu>

Ben Boyd
Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences
Monash University (Parkville Campus)
381 Royal Parade, Parkville
Victoria 3052, Australia
t: +61 3 99039112
f: +61 3 99039560
e: ben.boyd@monash.edu<mailto:ben.boyd@monash.edu>
w: http://www.pharm.monash.edu.au/staff/bjboyd.htm

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