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[SA_scat] ITC 2013: SAXS and computational techniques tostudy intrinsically disordered proteins

Dear Colleagues,

We announce the Intensive Training Course  2013: SAXS and  
computational techniques to study intrinsically disordered proteins.

EMBL, Hamburg, March 11-16, 2013

This Intensive Training Course is organized by a IDPbyNMR project  
(www.IDPbyNMR.eu), which is a Marie Curie activity funded under the  
European Commission FP7 people programme. The Course  is dedicated to  
application of Small Angle X-ray Scattering and Computational  
Techniques to studying of intrinsically disordered proteins (IDPs).  
The course includes theoretical lectures, tutorials on SAXS data  
analysis and computational techniques and measurements at the EMBL  
high brilliance synchrotron BioSAXS beamline P12 (storage ring  
PETRA-3, DESY). The theoretical part covers basics SAXS, sample  
preparation for the measurement, initial data processing approaches,  
ab initio and rigid body modeling, analysis of polydisperse systems,  
application of ensemble optimization method for studying of flexible  
proteins and incorporation of SAXS in molecular dynamics simulations .  
The methods combining NMR and SAXS data for a conformational  
description of IDPs will be presented. The practical part includes  
tutorials of ATSAS package programs, Asteroids and Flexible-Meccano  
software, measurements at the SAXS beamline and analysis of obtained  
data. Participants may bring their own samples to perform measurements  
on the beamline during the course. Students should bring their own  
laptops for tutorials.

Topics of the talks and tutorials:

? Introduction to SAXS

? Sample preparation and characterization

? Data reduction and processing

? Ab initio methods

? Rigid body refinement

? Mixture analysis

? Ensemble optimization method tutorial

? Asteroids software

? Flexible-Meccano method

? Incorporation of SAXS measurements as structural restraints in  
molecular dynamics simulations

How to Apply

This Intensive Training Course is open for up to 5 external students.  
The applicants should send an E-mail to erica@embl-hamburg.de  with CC  
to mkachala@embl-hamburg.de  and ?ITC 2013? as the subject indicating  
the following:

? Full name (name, last name)

? Birth date

? Nationality

? Affiliation

? Current position (PhD/post-doc)

? Brief abstract of applicants current research (max half of A4 size page)

? List of publications

? Letter of support by applicant?s supervisor.

The registration fee of 100 EUR should be paid in cash on-site.  
Selected applicants will have to cover their travel expenses and  
accommodation (the meals are included in the fee).

The application is open until 15th of February 2013.

Erica Valentini

Notkestrasse 85,
+49 040 899 02 182
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