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[SA_Scat] ACA 2018 - Small Angle Scattering Workshop

"Applications of Small Angle Scattering to Structural Biology: AnIntroduction." 
 
On behalf of the organizing committee, we are pleased to announce a workshopon "Applications of Small Angle Scattering to Structural Biology: AnIntroduction." 
 
This workshop will take place on Friday, July 20th, 2018 at this year'sAmerican Crystallographic Association (ACA) Meeting in Toronto, Canada. Themeeting itself will run from July 20-24.
Over the past two decades, SAS has become a mainstay technique for the studyof structure and composition in solution for structural biologists aroundthe world. In contrast to the more intensive SAS courses in Europe thatextend across several days, this single-day workshop will be comprised ofcarefully constructed lectures and tutorials to serve as an introduction toinvestigators new to the technique. The workshop format will includelectures and a selection of hands-on practical exercises.  Throughout theworkshop the emphasis will be on practical application: knowing how to judgedata quality, how to troubleshoot during data collection, and theexpectations for a successful experiment and acceptable publication.Students will also learn about aspects of home laboratory data collectionand will be introduced to experiments at national user facilities(synchrotrons and research reactors).   
 
Students will be expected to bring laptops with the appropriatepre-installed software. Extra laptops will be provided in case of unexpectedhardware or software issues on-site, and network connectivity will beprovided as part of the course, as some exercises and tutorials will replyon external computer-server resources. Preloaded portable disks and memorysticks will be provided to help reduce the need for large downloads overconference bandwidth.
We thank Anton-Paar, Rigaku Corporation, SAXSLAB, and Wyatt TechnologyCorporation for their kind support of this event.
Tentative Program Schedule
Time      Topic
8:00 AM    Registration and Software Installation Help; Speaker Introduction
8:30 AM    BioSAS: Overview 
Why is SAS helpful?
9:00 AM    The Scattering Profile 
Guinier analysis, concentration, monodispersity, etc.
9:30 AM    Tutorial 1: Basic Data Analysis I with RAW 
Is this good data? Radiation Damage?
10:00 AM   Coffee Break
10:15 AM   Data Analysis: Model-independent Features 
Molecular Weight Determination, Invariant Plots and Flexibility, The P(r)function
11:00 AM   Tutorial 2: Basic Data Analysis II with RAW 
Calculate a P(r) function, determine Molecular Weight, Dmax, Rg, Volume,etc.
12:00 PM   Working Lunch - Laboratory Source SAXS 
Discussion with Scientists, Experimental Advice
1:00 PM    SEC-SAXS 
Application and Practical Considerations
1:30 PM    Sample Preparation
Sample purification and preparation, aggregation, buffer selection, etc
1:45 PM    Complementary Biophysical Methods for Sample Assessment 
The importance of supporting biophysical methods including static anddynamic light scattering and analytical ultracentrifugation  
2:00 PM    Data Analysis: Model-dependent Analysis of SAS Data
Calculated scattering profiles from atomic models, Shape reconstruction,Atomistic modeling
2:30 PM    Tutorial 3: Three-dimensional modeling from SAS data
3:15 PM    Coffee Break
3:30 PM    Guest Research Lecture - Thomas Grant, Research Asst. Professor,University of Buffalo/Hauptman-Woodward Medical Research Institute
4:30 PM    SANS and Contrast Variation 
5:00 PM    Publishing SAS data 
5:30 PM    Conclusion
Pre-registration is mandatory. The fee to attend is: 
.             Student (undergrad, grad or postdoctoral) - $185 (CAN)
.             Corporate -  $355 (CAN)
.             Non-corporate or non-student - $185 (CAN)
Lunch will be included.
Contact: 
Kushol Gupta, Perelman School of Medicine, University of Pennsylvania.kgupta@upenn.edu
Confirmed Instructors:
Angela Criswell, Rigaku Corporation
Srinivas Chakravarthy, BioCAT Group, Advanced Photon Source
Richard Gillilan, Macromolecular Diffraction Facility, Cornell High EnergySynchrotron Source
Thomas Grant, University of Buffalo/Hauptman-Woodward Medical ResearchInstitute
Jesse Hopkins, BioCAT Group, Advanced Photon Source
Maxim Petoukhov, BIOSAXS Group, EMBL Hamburg
More information is available at:
http://www.amercrystalassn.org/2018-workshops   
http://www.amercrystalassn.org/2018-meeting-homepage 
 
 
 
Kushol Gupta, Ph.D.
Research Assistant Professor,<https://www.med.upenn.edu/biocbiop/index.html> Department of Biochemistryand Biophysics
Director,  <https://www.med.upenn.edu/biocbiop/jf/bsbcore/index.html>Johnson Foundation Structural Biology and Biophysics Core
 <http://www.med.upenn.edu/> Perelman School of Medicine at<http://www.upenn.edu/> The University of Pennsylvania
 <mailto:kgupta@upenn.edu> kgupta@upenn.edu / 267.259.0082 /<http://www.stwing.upenn.edu/~kgupta> www.stwing.upenn.edu/~kgupta
 
 
 
 
 
 
 
 
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