Crystallography around the world: Singapore
Regional Committee of Crystallographers from Indonesia, Malaysia, Thailand and Vietnam
Regional Committee of Crystallographers from Indonesia, Malaysia, Thailand and Vietnam
Secretary of National Committee
DUONG NGOC HUYEN, Hanoi University of Science and Technology, No. 1 Daicoviet, Hanoi, Vietnam
J.J. VITTAL (Chair)
SITI NADIAH ABDUL HALIM
DUONG NGOC HUYEN
This information last updated: 13 Jul 2018
The following crystallographers in Singapore are registered in the World Directory of Crystallographers.
43 entries found
- Adams, Professor Dr Stefan Associate Professor. Stefan Adams, National University of Singapore, Department of Materials Science & Eng., Faculty of Engineering, Blk E2, #05-22, 5 Engineering Drive 2, Singapore 117579, SINGAPORE.
- Aitipamula, Dr Srinivasulu Senior Research Fellow. Crystallization and Particle Sciences, Institute of Chemical and Engineering Sciences, 1, Pesek Road, Singapore, 627833, Singapore, Singapore.
- Ang, Dr Siau-Gek Associate Professor. Dept. of Chemistry, Nat. U. of Singapore, Kent Ridge, 0511, Singapore, Singapore.
- Bugarin, Mr Enrico Paolo Maths Teacher. St Joseph's Institution, -, -, Singapore, Singapore.
- Chan, Mr Wee Lee Medical Student. Duke-NUS Medical School, 8 College Road, 169857, Singapore, Singapore.
- Chanthapally, Dr Anjana ?. Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Kent Ridge Campus, Singapore.
- Chen, Ms Qinming student. School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, singapore, 637551, singapore, Singapore.
- Chen, Mr Yun Student. School of Biological Sciences, Nanyang Techonological University, 61 Biopolis Drive (Proteos) #7-04, Singapore, 138673, Singapore, Singapore.
- Chowdari, Professor B.V.R. Assoc. Prof.. Dept. of Physics Nat. U. of Singapore Kent Ridge, 0511, Singapore, Singapore.
- CHUI, Dr STEPHEN SIN-YIN Lecturer. Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore, Singapore.
- Clarke, Dr Neil D. Senior Group Leader. Genome Institute of Singapore, 60 Biopolis Street, 138672, Singapore, Singapore.
- Ganguly, Dr Rakesh Senior Research Fellow. Chemistry and Biological Chemistry, Nanyang Technological University, SPMS-01-18D, 21 Nanyang Link, 637371, Singapore, Singapore.
- Guo, Dr liangfeng Researcher. Process Science and Modelling, Institute of Chemical & Engineering Sciences (ICES), 1 Pesek Road, Jurong Island, Singapore, 627833, Singapore, Singapore.
- Gupta, Dr Anjali Bansal Post doctoral Research Fellow. Mechanobiology Institute, Mechanobiology Institute, NUS, Singapore, level 10, T-lab building, 5A Engineering Drive 1, Singapore, 117411, Singapore, Singapore.
- Jayaraman, Dr Sivaraman Associate Professor. Dr J.Sivaraman, Department of Biological Sciences, 14 Scienec Drive 4, National University of Singapore, Singapore 117543.
- Jobichen, Dr Chacko Senior Research Fellow. Biological Sciences, National University of Singapore, Singapore, Singapore, 117543, Singapore, Singapore.
- Kumar, Dr Sundramurthy Operations Manager, Scientific Services. X-ray Crystallography, Biopolis Shared Facility, BMSI, A*STAR, 30, Biopolis Street #B2 Centros, 13867, Singapore, Singapore.
- Kumar, Dr Veerendra Post Doc. NISB, Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Proteos, Singapore.
- Kuok, Dr Meng Hau Professor. Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117542, Republic of Singapore.
- Leong, Dr Weng Kee Associate Professor. Chemistry and Biological Chemistry, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore, Singapore.
- LESCAR, Dr Julien Associate Professor. School of Biological Sciences, Nanyang Technological University, 60, Nanyang Drive, 637515, Singapore, Singapore.
- Li, Dr Yongxin Manager (X-ray Crystallography). Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore, 637371, Singapore, Singapore.
- Loh, Dr Ne-Te Duane Postdoctoral Fellow. Centre for BioImaging Sciences, National University of Singapore, 14 Science Drive 4, 117543, Singapore, Singapore.
- Lu, Ms Wenlai Graduate Student. Materials Science and Engineering, National University of Singapore, Blk EA, #03-09, 9 Engineering Drive 1, Singapore, 117576, Singapore, Singapore.
- Malathy Sony, Dr Subramanian Manimekalai Research Fellow. Biological Sciences, Nanyang Technological University, 60, Nanyang Drive, 637551, Singapore, Singapore.
- Medishetty, Mr Raghavender Graduate student (Ph. D). Department of chemistry, National University of Singapore, 3, Science drive-3, National University of Singapore, Singapore, 117543, Singapore, Singapore.
- Meshcheryakov, Dr Vladimir Researcher. 28 Medical Drive, 117456, Singapore, Singapore.
- Mok, Dr Kum-fun retired. Nanyang Technological University, -, -, Singapore, Singapore.
- Mukherjee, Mr Manjeet Graduate Student at National University of Singapore. S3, Level 4, Structural Biology Lab 5, Department of Biological Science, National University of Singapore, 14 Science Drive 4, Singapore 117543.
- Ng, Professor Ser Choon Prof.. Dept. of Physics Nat. U. of Singapore Kent Ridge, 0511, Singapore, Singapore.
- RAJAN, Dr SREEKANTH Senior Research Fellow. Biological Sciences, Nanyang Technological University, -, -, Singapore, Singapore.
- Saravanan, Mr Vivekanandan Research Fellow. Biological Science, Genome Institute of Singapore, Science Drive 4, Singapore, 117543, Singapore, Singapore.
- Schreyer, Dr Martin Senior Research Fellow. Malvern Panalytical, 31 Kaki Bukit Road 3, 417818, Singapore, Singapore.
- seck, Dr hon luen Researcher. 71 Nanyang Drive, 638075, Singapore, Singapore.
- Swaminathan, Kunchithapadam Associate Professor. Biological Sciences, National University of Singapore, Blk S3, Room 03-02, 117543, Singapore, Singapore.
- Teh, Dr Hung Chuan Sr. Lect., retired. Information Systems and Computer Sci. Dept, National University of Singapore, Kent Ridge, 0511, Singapore, Singapore.
- Tria, Mr Giancarlo Postdoctoral Research Fellow. Structural Biology and Biochemistry, Nanyang Technological University, SBS-03s-48, 60 Nanyang Drive, -, Singapore, Singapore.
- VITTAL, Professor Jagadese Professor. Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore, Singapore.
- White, Professor Tim Professor. Materials Science & Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore, Singapore.
- Yang, Dr Ping Researcher. Singapore Synchrotron Light Source (SSLS), National University of Singapore (NUS), 5 Research Link, 117603, Singapore, Singapore.
- Ye, Mr Fuzhou PhD student. 61 Biopolis drive, proteos #7-04,Singapore, 138673.
- YU, Dr Zai-Qun R&D. Crystallization and Particle Science, Institute of Chemical and Engineering Sciences, 1 Pesek Road, 627833, Jurong Island, Singapore.
Reports of past activities in Singapore
This is a concise listing of all events in this country that are associated with the International Year of Crystallography 2014 and its follow-up initiatives.
|14th Dec 2014||8th Singapore International Chemistry Conference 2014 Department of Chemistry, National University of Singapore, Singapore|
|11th Singapore National Crystal Growing Challenge Singapore The biennial crystal growing challenge opened to students in secondary schools, international schools, junior colleges, ITE colleges and polytechnics in Singapore.|
This Special Report was published in the IUCr Newsletter, Vol. 14, No. 3 (2006).
Crystallography in Singapore
Swami begins with his experience when he decided to move to Singapore. “In 1998, the most important doubt for my then 8 year old son was whether pizza would be available there. With my knowledge of geography and his level of comprehension I convinced him that Singapore is just an extension of California but there is a big ocean in-between. I even managed to make him believe that there would be bus service between Singapore and Los Angeles. After moving to Singapore I learned very soon that the kids of my ‘expat’ (a term we use here for foreign workers) colleagues had similar doubts about burritos, sushi, masala dosa and so on”.
Singapore is a small island of about 690 sq. km with a population of ~4 million people. It is essentially a city country with no natural resources, but this has not hampered the country’s growth since its independence from Malaysia in 1965. Within a short span of time Singapore has become a highly developed country with a successful free market economy. Until the beginning of the 1990s Singapore was known mostly for economical shopping. Recently, it has become a choice destination for scientists, especially crystallographers as can be seen from the increase in the number of crystallographers and research areas over the past 10 years.
“Crystallography is very new to Singapore”, according to Lip Lin Koh who returned to Singapore in 1964 from Boston University. He was not aware of any crystallographic research or teaching in Singapore or Malaysia at that time. All three universities (U of Malaya at Kuala Lumpur, U of Malaya at Singapore and Nanyang University, Singapore) had Physics and Chemistry departments, but crystallography was not part of the curriculum. He was the first to introduce crystallography as part of Physical Chemistry. In the mid 1970’s, he was able to obtain a table-top X-ray unit, a Weissenburg camera and a Debye-Scherr camera. These were mainly used for demonstration and simple experiments and projects for senior undergraduate students. The first crystal structure publication from Singapore was: Thianthrene gold (III) chloride (chloroform solvate) at -70 ºC. N.W. Alcock, K.P. Ang, K.F. Mok, and S.F. Tan. Acta Cryst., B34, 3364 (1978). K.P. Ang was a former head of the chemistry department, National University of Singapore (NUS) and S.F. Tan was an emeritus professor in the same department.
It was only in October 1989 that the first single crystal X-ray diffractometer (a Siemens P3) with a MicroVax computer arrived at the Department of Chemistry, NUS. Koh says, “It was with this instrument that I was able to become a crystallographer again, picking up my skills after 20 years! Luckily, I still remembered my crystallography, thanks to the physical chemistry that I had been teaching and my sabbatical leave in 1987”. The first researchers to actually use the diffractometer were: K.F. Mok (after retirement he moved to Nanyang Technological University (NTU)), and W.L. Kwik (deceased), followed by Y. Lam andY. Xu (Koh’s postdoc from 1992 to 1995). Xu left for the National Institute of Education (NIE) in 1996 to start her own X-ray crystallography lab equipped with a P4 diffractometer. The current service facility at the Department of Chemistry, NUS was established in 1997 when the first Siemens SMART 1000 CCD diffractometer arrived, and Jagadese J. Vittal, an experienced chemical crystallographer from Canada, joined the faculty. Now more than 20 faculty members from the department of chemistry and their research groups routinely use this facility.
Macromolecular crystallography in Singapore started in 1997 after Prasanna Kolatkar arrived. Also Nam-Hai Chua, one of the founding professors of the Institute of Molecular and Cell Biology (IMCB, 1987) established the Institute of Molecular Agrobiology in 1995 (now called Temasek Lifescience Laboratories, TLL) and recruited some of the early birds in 1998. Subsequently, the Singapore government has undertaken a strong commitment to promote Singapore as a biotechnology power-house in this region. Through the National Science and Technology Board, which is now known as the Agency for Science, Technology and Research (A*STAR), the government has established more research institutes. In addition, NTU established its School of Biological Sciences and recruited several crystallographers. In summary, the two universities, NUS and NTU (with their appropriate departments or schools), and several research institutes, like IMCB, Genome Institute of Singapore (GIS) and TLL, are now very actively involved in macromolecular crystallographic research.
Jagadese J. Vittal confessed that he was really afraid of symmetry and space groups when he was a graduate student. During his postdoc at the University of Western Ontario he was encouraged to take the crystallographic course offered in the Chemistry Department. He fondly recalls that his mentor in crystallography, Nicholas Payne, “was a dedicated crystallographer who really enjoyed teaching crystallography. He patiently taught me to be a well-rounded crystallographer”. Later Vittal was a service crystallographer in the same department before he accepted a position at NUS in 1997. The Siemens CCD diffractometer, installed in the Department of Chemistry at NUS in 1997 was not only the first one in Singapore but also in that region and it was one of the reasons Vittal moved to Singapore.
Yulin Lam, from the Department of Chemistry, NUS, is one of a very few Singaporeans trained and currently practicing chemical crystallography in Singapore. She received her PhD from NUS (Supervisor: Hsing Hua Huang) in the area of conformational analysis. She was a Research Fellow at the Scripps Research Institute and the Institute of Molecular and Cell Biology in Singapore before joining NUS. Her research interest includes combinatorial chemistry, structure-based and pharmacophore-based drug design and conformational analysis.
Siau Gek Ang is one of the chemistry faculty members who is interested in the application of spectroscopic techniques and X-ray diffraction methods. Her research interests include bioactive compounds from Chinese herbs and the organometallic chemistry of osmium and ruthenium. Currently she is Registrar of NUS.
Weng Kee Leong is using single crystal X-ray crystallographic techniques to elucidate the solid-state structures of newly synthesized heteronuclear and intermetallic clusters, nanomaterials and heterogeneous, and homogeneous catalysts.
Feng Xu, a new member of the chemistry faculty of NUS, is interested in both chemical crystallography and macromolecular chemistry. He learned chemical crystallography as a graduate student in the Chinese University of Hong Kong under Tomas C.W. Mak. He worked in macromolecular crystallography at the Wistar Institute, Philadelphia, USA before coming to Singapore in 2005. He is interested in supramolecular chemistry and crystal engineering of hydrogen-bonded molecular solids; design and control of molecular assemblies and packing arrangements to generate crystals with specific properties as new materials and drugs; structural biology of viruses by X-ray crystallography; molecular modeling and electron microscopy;and understanding protein structure and its biological function for pharmaceutical application.
Kum Fun Mok is one of the distinguished crystallographers in Singapore. After retirement from the Department of Chemistry, NUS, he established the X-ray Crystallography unit for the Division of Chemistry and Biological Chemistry, NTU along with his former student Yongxin Li.
Fig. 2.4. (a)The crystalliser system with ATR-FTIR and FBRM monitoring and control. (b) Spray-dried large hollow nano-particulate aggregate of 20 nm silica nano-particles. (c) Monosized nanoporous siliceous submicron excipient particles, synthesized via a novel environmentally benign dry gel conversion route.
Nobel Laureate Robert Huber is a visiting faculty member at the Department of Chemistry, NUS and teaches an MSc Industrial Chemistry course, jointly offered by NUS and the Technical University of Munich. He is a familiar face at the NUS campus.
Swami says, “My first day in Singapore was laced with childhood memories. Interestingly, in third grade (1969) in my village school, a friend’s grandfather returned to our village after a trip to Singapore. In fact, we used to call him ‘the great man who traveled in a ship’. He presented me with a pencil with a small eraser attached at the end. Even today, this pencil is one of my most unforgettable surprises. After that I saw Singapore in several Indian films. However, I never had a chance to come here”.
Bob’s main interest is in understanding the mechanisms behind cell movement. The Lab focuses on actin polymerization machinery (related structures above), which provides the force during cell locomotion. “We use protein crystallography to determine the shape of key molecular complexes that regulate the spatial and temporal patterning of actin assembly and disassembly. In the long term we would like to design drugs to interfere with these processes, with the aim of stopping pathogens and cancer cells from invading tissues or to speed up the recruitment of repair cells to wound sites.”
In Singapore, research in the biological sciences is on the rise. The current funding atmosphere holds special promise for investigators who are embarking on novel research avenues or engaging in unique interdisciplinary ventures. For the hard-core X-ray crystallographer, the only major item to wish for would be to have our own macromolecular synchrotron facility!”
The latest addition to our club is Adam Yuan (another bigamist) from Memorial Sloan Kettering Cancer Center, New York. He will have a joint appointment with Temasek Life Science Laboratory and the Department of Biological Sciences, National University of Singapore.
Singapore Synchrotron Light Source (SSLS)
The XDD beamline was designed for general-purpose diffractometry including high-resolution diffractometry, powder diffractometry, reflectometry, and topography. It also features XAFS (Xray absorption fine structure). With high-resolution diffractometry, precise structural parameters, minute strain status, composition, thickness, surface/interface roughness and texture/stress analysis for crystalline materials can be obtained. Powder diffractometry makes possible crystal structure determination and refinement, phase identification both in quality and quantity, precise lattice-parameter determination, measurement of crystal grain size & texture/stress analyses. With grazing-incidence-diffraction, reflectometry and diffuse scattering, information on surface and interface structure ordering, as well as surface phase identification/transition can be obtained. XAFS can offer information on neighboring coordination and valence status in a complex, particularly for non-crystalline materials.
SSLS has proposed to disentangle the methods currently combined in XDD and to build dedicated beamlines for powder diffraction, for long-wavelength macromolecular structure determination enabling phasing from phosphorus up (2.149 keV) and for X-ray absorption fine structure spectroscopy, all of them serving research institutes, universities, and industry, locally as well as regionally. They are also slowly expanding in other areas like XAFS, XANES (X-ray absorption near edge structure) and reflectometry.
Conferences, meetings and workshops
Asian Crystallographic Association Meeting (AsCA’92): The Inaugural AsCA Conference was held in Singapore, in November 1992. The Crystallographic Society of Japan and the Society of Crystallographers in Australia and New Zealand supported this by holding their annual meetings at AsCA’92. Syd Hall of Western Australia was the conference chairman and Lip Lin Koh chaired the local organizing committee. The then President of the IUCr, Andre Authier, attended the meeting. The total registration was 320 from more than 20 countries with 260 full participants and 60 students, excluding 30 accompanying persons. The scientific program consisted of 16 oral sessions with 73 papers and 22 poster topics with 190 papers.
International Conference of Structural Biology: The Department of Biological Sciences hosted three International Structural Biology Conferences (2000, 2002 and 2004). The participants of the 2004 conference included Jack Johnson, Susan Taylor and Roger Tsien. Very importantly, in the 2004 conference they conducted a 3 day crystallography workshop that covered all aspects of crystallography. The workshop was free and about 50 graduate students from countries like India, China, and Malaysia attended. The Department of Biological Sciences is now gearing up for the 4th conference in December 2006.
Kunchithapadam Swaminathan and Jagadese J. Vittal
Singapore’s leading crystallographer
He rejoined the Department as an Adjunct Senior Research Fellow in 1992, offering selfless guidance to staff and students on solving crystal structures. He was the first Singaporean to serve as a co-editor of the scientific journal Acta Crystallographica (during the period 1994-97). He organized the first AsCA Meeting in 1992. He has been helping the Singapore National Crystal Growing Challenge organizers in selecting the winners.
Photographic record of crystallographic activities in Singapore
|The complete IUCr photographic archive includes thousands of photographs. Here we include a collection illustrating activities in this country. This image is selected randomly from the galleries listed below (AsCA Meeting, 1992).|
|Yuji Ohashi (left).|