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[SA_Scat] CBMS Lecture Series - 22 September - Chris Brosey

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  • Subject: [SA_Scat] CBMS Lecture Series - 22 September - Chris Brosey
  • From: "Stojanoff, Vivian via sa_scat" <sa_scat@iucr.org>
  • Date: Tue, 14 Sep 2021 16:12:43 +0000
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Please join us ………..

Center for Biomolecular Structure Lecture Series


Incorporating HT-SAXS into Structure-Driven Drug Discovery Pipelines

Chris Brosey

M.D. Anderson Cancer Center, The University of Texas

WEDNESDAY, September 22, 13:30 (EST - NY time zone)


Register in advance for this meeting:
   https://bnl.zoomgov.com/meeting/register/vJIsfu6przwpH8NymLh_TKxtg09_NaMkFFs


Abstract:
High-throughput (HT) methods for discovering single-target protein and nucleic acid ligands are well established and routinely utilized for drug discovery. Many critical biological outcomes, however, are mediated by multi-component assemblies and dynamic macromolecular architectures. HT approaches to assess and fine-tune ligand impact on such functional, dynamic systems remain underdeveloped. Small-angle X-ray scattering (SAXS) provides an opportunity to monitor changes to biomolecular architectures and assemblies under native solution environments, enabling chemical screening and selection for specific architectural states. I will discuss how we have incorporated time-resolved HT-SAXS into a classic fragment screening pipeline and used this approach to identify chemical allosteric effectors targeting functional architectures of mitochondrial Apoptosis-Inducing Factor (AIF)
-----------------------------------------------Vivian Stojanoff, PhDEducation, Training, OutreachUser Programp 1(631) 344 8375e nsls.lifesciences@gmail.com<mailto:nsls.lifesciences@gmail.com>w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/>
Address:Center for Biomolecular StructureNational Synchrotron Light Source IIBuilding 745Brookhaven National LaboratoryUpton NY 11973
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