Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate
The structure of
Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase (
Gs6PGDH) complexed with 6-phosphogluconate is reported. 6PGDH is a highly conserved enzyme with conservation most pronounced in the N- and C-terminal domains, which contribute to the active site, compared with the central domain, which is involved in dimerization. 6PGDH is a potential drug target for the parasite
Trypanosoma brucei, which causes African sleeping sickness. The
T. brucei enzyme is unsuited for ligand studies but the straightforward crystallization means that
Gs6PGDH provides a surrogate model for inhibitor design.
S. Cameron, V.P. Martini, J. Iulek and W.N. Hunter