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RIKEN - Daresbury - Liverpool Structural Genomics

Acta Cryst. (2009). F65, 1200-1203 (; 1204-1208 (; 1209-1213 (; 1214-1217 (; 1218-1221 (; 1222-1226 (; 1227-1233 (; 1234-1239 (

[Pyridoxal 5'-phosphate] Pyridoxal 5ʹ-phosphate (green sticks) bound to the active site of a putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus.

On 20 January 2009 an MOU was signed between RIKEN SPring-8 Center (Japan) and the University of Liverpool (UK). In December Acta Cryst. F published the first fruits of this collaboration, which is extended to include the RIKEN Systems and Structural Biology Center: eight crystal structures from four organisms. A common themein these structures was the presence at active sites of co-factors, substrate and product molecules, such as NAD+, NADP+, lactate, pyruvate and pyridoxal 5'-phosphate, all of which were endogenous to the protein expression systems.

Y. Agari, S.V. Antonyuk, Y. Bessho, A. Ebihara, M.J. Ellis, S.S. Hasnain, H. Iino, Y. Inoue, S. Kuramitsu, A.D. Malay, B. Padmanabhan, A. Shinkai, R.W. Strange, N. Watanabe and S. Yokoyama