RIKEN - Daresbury - Liverpool Structural Genomics

Acta Cryst. (2009). F65, 1200-1203 (doi.org/10.1107/S1744309109043772); 1204-1208 (doi.org/10.1107/S1744309109043814); 1209-1213 (doi.org/10.1107/S1744309109044935); 1214-1217 (doi.org/10.1107/S1744309109044923); 1218-1221 (doi.org/10.1107/S1744309109046302); 1222-1226 (doi.org/10.1107/S174430910904651X); 1227-1233 (doi.org/10.1107/S1744309109047046); 1234-1239 (doi.org/10.1107/S1744309109050052)

Pyridoxal 5ʹ-phosphate (green sticks) bound to the active site of a putative 4-amino-4-deoxychorismate lyase from Thermus thermophilus.

On 20 January 2009 an MOU was signed between RIKEN SPring-8 Center (Japan) and the University of Liverpool (UK). In December Acta Cryst. F published the first fruits of this collaboration, which is extended to include the RIKEN Systems and Structural Biology Center: eight crystal structures from four organisms. A common themein these structures was the presence at active sites of co-factors, substrate and product molecules, such as NAD⁺, NADP⁺, lactate, pyruvate and pyridoxal 5'-phosphate, all of which were endogenous to the protein expression systems.