IUCr journals news
Papers from Second International Workshop on X-ray Damage to Crystalline Biological Samples
J. Synchrotron Rad. (2002). 9, 327–381
Macromolecular crystallographers are now actively investigating radiation damage processes in cryo-cooled (around 100 K) crystals. The aim is to understand them well enough to design minimization and/or mitigation strategies so that intense undulator-produced synchrotron beams can be fully utilized.
The November 2002 issue of the Journal of Synchrotron Radiation contains a collection of eight papers on this topic, with an introduction summarising the current status (Garman and Nave). Among the reported experimental results is evidence, provided by reduced specific structural damage and absorption spectra collected with a microspectrophotometer, that the introduction of a radical scavenger (0.5 M ascorbate co-crystallised with HEWL) can prolong the crystal lifetime in the x-ray beam (Murray and Garman). Physical and chemical processes relevant to the damage process are also discussed (O’Neill, Stevens and Garman).