IUCr journals

Increase of lifespan for glioma-bearing rats by using minibeam radiation therapy

J. Synchrotron Rad. (2012). 19, 60–65 (http://doi.org/dk88n6)

[Survival plots] Survival curves (as a function of time) of 9L gliosarcoma-bearing rats for different doses. The responses of both the control rats (CTRL) and the rats receiving one fraction minibeam radiation therapy in unidirectional and interlaced configurations are shown.

A new radiotherapy technique, minibeam radiation therapy (MBRT), is under development at the European Synchrotron Radiation Facility. It combines submillimetric field sizes (500–700 µm) and a spatial fractionation of dose, which leads to exceptional normal tissue dose tolerances. This might permit the use of potentially curative doses in some radioresistant tumors, like gliomas. This work reports a dose escalation study performed on 9L gliosarcoma-bearing rats. A factor of three gain in mean survival time paves the way for further exploration of different possibilities of MBRT.

Y. Prezado, S. Sarun, S. Gil, P. Deman, A. Bouchet and G. Le Duc