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Miscellany
Structure and drug design
Several marketed drugs, including protease inhibitors used in the treatment of AIDS, have been designed using the 3-D x-ray structure of a target protein as a template for structure based antagonist design. Current and future developments in the high-throughput expression, purification, crystallization, and x-ray structure determination of large numbers of proteins promise to yield many more successes in the future.
M.E. Wolff, President, Intellepharm Inc., C & E News, Sept. 18, 2000.