International School of CrystallographyErice, Italy, 2-11 June 2017
Over the past decades, crystallography has developed from a method capable of determining the structures of isolated soluble proteins to one able to provide detailed information on the mechanisms of action of integral membrane proteins, whole viruses and the complex nano-machines that are central to cellular function. To discover how biology works, researchers are now combining the power of crystallography with a multiplicity of other methods, spanning from the atomic to the cellular scale, and including revolutionary developments in electron cryo-microscopy and tomography. This Course will celebrate its milestone as the 50th in the crystallography series started by Dorothy Hodgkin by focusing on integration: 1) of different techniques, 2) of molecular and cellular approaches and 3) of the crystallographic community, including diversity.
The aim is to provide young researchers with a review of the fundamental approaches and latest developments in the application of crystallography and hybrid methods to the structure and function of biological macromolecules and complexes. Lectures will exemplify the use of integrated approaches to analyse molecular mechanisms in human and pathogen biology. There will be hands-on workshops to provide practical experience and in-depth discussion of topics ranging from sample preparation to data analysis software. To commemorate the achievements of the Erice Crystallography School over the past 50 years, the course will feature several sessions that reflect on the past and look to the future to highlight the factors that create an inclusive discipline.
The program will include a session about the history of the School illustrated by preeminent scientists that attended the course in these years.Annalisa Guerri