Ezetimibe monohydrate

Acta Cryst. (2005). E61, o2907–o2909

This paper describes the structure of a medicinally important compound, belonging to a class of agents that inhibit cholesterol absorption in the intestine. It has a favorable pharmacokinetic profile, which allows it to be administered daily and to be given in conjunction with a statin. Considering the X-ray crystal structure from the point of view of a structure–activity model, it may be speculated that the binding site accommodates a “T” shape, with the two arm ends occupied by the two fluorophenyl rings and the tail end by the hydroxyphenyl ring, while the azetidinone ring is located at the junction.

Krishnan Ravikumar and Balasubramanian Sridhar