Structure of mouse ADP-ribosylhydrolase 3 (mARH3)
ADP-ribosylation is a reversible posttranslational modification that modulates protein activity in pro- and eukaryotes. The reaction is catalysed by ADP-ribosyltransferases (ARTs) and ADP-ribosylhydrolases (ARHs), respectively. ARTs and ARHs have been divided into a number of subfamilies that are thought to confer substrate specificity. The structure of mouse ADP-ribosylhydrolase 3 has been solved to a resolution of 1.8 Å and is featured as an interactive figure in this publication. Two Mg ions are located in a cleft on the protein surface that pinpoint the active site.
C. Mueller-Dieckmann, S. Kernstock, J. Mueller-Dieckmann, M.S. Weiss and F. Koch-Nolte