IUCr journals

Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron

Acta Cryst. (2010). F66, 1297-1305 (doi.org/10.1107/S1744309110023055)

[MACPF protein] Structure of BT_3439.

MACPF proteins are important in human immunity and in virulence of pathogens due to their ability to compromise membrane integrity by forming transmembrane pores. The structure of an MACPF-domain-containing protein BT_3439, a potential toxin from a gut symbiont, contains an MACPF domain and two novel C-terminal domains (D2, D3) that have not been observed in previous MACPF structures. The MACPF proteins from Bacteroidetes were likely acquired independently from a eukaryotic origin via horizontal gene transfer to adapt better to the host environment.

Q. Xu et al.