Conformational change of the AcrR regulator reveals a possible mechanism of induction
Escherichia coli AcrR represses transcription of
acrAB and is induced by many structurally unrelated cytotoxic compounds. The crystal structure of this regulator in space group
P222
1 has been reported previously, revealing a dimeric two-domain molecule with an entirely helical architecture similar to members of the TetR family of transcriptional regulators. Here, a crystal structure of this regulator in space group
P3
1 is presented. A comparison of the two AcrR structures reveals possible mechanisms of ligand binding and AcrR regulation.
R. Gu, M. Li, C.-C. Su, F. Long, M.D. Routh, F. Yang, G. McDermott and E.W. Yu