This issue contains reports for all of the microsymposia on High Pressure Crystallography from the Glasgow IUCr Congress. The reports were collected and edited by Commission Chair Richard Nelmes. Richard organized the High Pressure sessions at the IUCr Congresses in Seattle and Glasgow with great care from the planning process right through execution and preparation of final reports setting a standard that other commission chairs may want to emulate.
The cover has a number of possible interpretations. The Cohen/ Houdusse structures upon which it is based exemplifies the value of studying the same molecule under different conditions to understand its capabilities and correlate changes with molecular function. The replication of many copies of the structure on the cover alludes to the evolution of families of proteins. The march of the molecules can be seen as robotic movement of molecular lemmings. It suggests the mind-numbing prospect of structure for the sake of structure with biochemists and crystallographers potentially so overwhelmed with new structural information that they haven't the time or ability to think about the meaning or functions of structures in any significant and thoughtful way.
I have been gathering material related to the role of crystallography in the genome project for over two years. On pages 18-20, we have reprinted Carolyn Cohen's remarks, along with my observations and those of others on the challenge of structural genomics.Bill Duax