You can fold some of the proteins all of the timeA technique for identifying folding patterns of proteins using mass spectrometry that is potentially faster and requires less sample than X-ray crystallographic or NMR methods has been developed by B.W. Gibson and I.D. Kuntz. They believe the time needed to determine the fold family of a protein can be reduced to one week and that less than 10mg of protein may be required to elucidate macromolecular interactions, and multiple conformational states, and to contribute to the design of protein mimetics.
C&EN, June 5, 2000